Skip to main content
SpringerLink
Log in
Book cover

Genetics of the Epilepsies pp 191–208Cite as

Perspectives: Clues in Mapping Epilepsy Genes

  • Conference paper

Abstract

Soon it will be possible to practice medicine at a molecular level and identify gene products by mapping genes for a growing number of diseases, including the epilepsies. The chromosomal locations of about 900 structural genes are now known, representing less than 2% of the total 50 000 genes estimated for man (McKusick [50]). In addition, 500 anonymous DNA segments have been mapped to specific human chromosomes and many of these human genes have sequence variations, making them useful linkage markers.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Allen FH Jr (1974) Linkage of HLA and GBG. Vox Sang 27: 383–384

    Google Scholar 

  2. Amos DB, Kostyu DD (1980) HLA — a central immunological agency of man. Adv Hum Genet 10: 137

    PubMed  CAS  Google Scholar 

  3. Askanas V, Engel WK, Britton DE, Adornato BT, Eiben RM (1978) Reincarnation in cultured muscle of mitochondrial abnormalities. Two patients with epilepsy and lactic acidosis. Arch Neurol 35: 801–809

    Google Scholar 

  4. Bird TD, Ott J, Giblett ER (1982) Evidence for linkage of Charcot-Marie-Tooth neuropathy to the Duffy locus on chromosome 1. Am J Hum Genet 34: 388–394

    PubMed  CAS  Google Scholar 

  5. Bongiovanni AM (1978) Congenital adrenal hyperplasia and related conditions. In Stanbury JB, Wyngaarden JB, Fredrickson DS (eds) The metabolic basis of inherited disease. McGraw-Hill, New York, p 868

    Google Scholar 

  6. Botstein D, White RL, Skolnick M, Davis RW (1980) Construction of a genetic linkage map in man using restriction fragment length polymorphisms. Am J Hum Genet 32: 314–331

    PubMed  CAS  Google Scholar 

  7. Caskey CT, White RI (eds) (1983) Banbury report 14: Recombinant DNA applications to human disease. Cold Spring Harbor, NY, Cold Spring Harbor Laboratory

    Google Scholar 

  8. Collins FS, Weissman SM (1984) Directional cloning of DNA fragments at a large distance from an initial probe: a circulation method. Proc Natl Acad Sci Genet USA 81: 6812–6816

    Article  CAS  Google Scholar 

  9. Conneally PM, Rivas MC (1980) Linkage analysis in man Adv Hum Genet 10: 209–266

    CAS  Google Scholar 

  10. Delgado-Escueta AV, Enrile-Bacsal F (1984) Juvenile myoclonic epilepsy of Janz. Neurology (NY) 34: 285–294

    CAS  Google Scholar 

  11. Delgado-Escueta AV, Greenberg D (1984) The search for epilepsies ideal for clinical and molecular genetic studies. Ann Neurol 16 (suppl) 2: 1–11

    Google Scholar 

  12. Delgado-Escueta AV, Treiman DM, Walsh GO (1983) The treatable epilepsies. N Engl J Med 308: 1508–1514

    Article  PubMed  CAS  Google Scholar 

  13. Delgado-Escueta AV, Treiman DM, Walsh GO (1983) The treatable epilepsies. N Engl J Med 308: 1576–1584

    Article  PubMed  CAS  Google Scholar 

  14. Delgado-Escueta AV, White R, Greenberg DA, Treiman LJ (1986) Looking for epilepsy genes: clinical and molecular genetic studies. In: Delgado-Escueta AV, Ward AA Jr, Woodbury DM, Porter RJ (eds) Advances in neurology, vol 44. New York, pp 77–95

    Google Scholar 

  15. DeLorenzo RJ (1986) A molecular approach to the calcium signal in brain: Relationship to synaptic modulation and seizure discharge. In: Delgado-Escueta AV, Ward AA Jr, Woodbury DM, Porter RJ (eds) Advances in neurology, vol 44. New York, pp 435–465

    Google Scholar 

  16. Doose H, Gundel A (1982) 4 to 7 CPS rhythms in the childhood EEG. In: Anderson VE, Hauser WA, Penry JK, Sing CF (eds) Genetic basis of the epilepsies. Raven, New York, pp 83–93

    Google Scholar 

  17. Doose H, Scheffner D (1982) Zur Therapie und Prognose der Absencen. Med Welt, pp 1763–1767

    Google Scholar 

  18. Doose H, Gerken H, Hien-Völpel KF, Völzke E (1969) Genetics of photosensitive epilepsy. Neuropaediatrie 1: 56–73

    Article  CAS  Google Scholar 

  19. Doose H, Gerken H, Leonhardt R, Völzke E, VÖ1Z C (1970) Centrencephalic myoclonicastatic petit mal. Neuropädiatrie 2: 59–78

    CAS  Google Scholar 

  20. Doose H, Gerken H, Horstmann T, Völzke E (1973) Genetic factors in spike wave absences. Epilepsia 14: 57–75

    Article  PubMed  CAS  Google Scholar 

  21. Dupont B, Smithwick EM, Oberfield SE, Lee TD, Levine LS (1977) Close genetic linkage between HLA and congenital adrenal hyperplasia (21-hydroxylase deficiency). Lancet II: 1309–1312

    Google Scholar 

  22. Eeg-Olofsson O, Safwenberg J, Wigertz A (1982) HLA and epilepsy: an investigation of different types of epilepsy in children and their families. Epilepsia 23: 27–34

    Article  PubMed  CAS  Google Scholar 

  23. Fichsel H, Kessler M (1980) Immunogenetics of 3/s-SW absence epilepsy: frequency of HLA antigeness and haplotypes in patients and relatives. In: Canger R, Angeleri F, Penry JK (eds) Advances in epileptology (11th epilepsy international symposium). Raven, New York, pp 475–477

    Google Scholar 

  24. Fischer SG, Lerman LS (1983) DNA fragments differing by single base-pair substitutions are separated in denaturing gradient gels: correspondence with melting theory. Proc Natl Acad Sci USA 80 (6): 1579–1583

    Article  PubMed  CAS  Google Scholar 

  25. Gedda L, Tatarelli R (1971) Essential isochronic epilepsy in MZ twin pairs. Acta Genet Med 20: 380–383

    CAS  Google Scholar 

  26. Grisar T, Franck G, Delgado-Escueta AV (1983) Glial contribution to seizures: K+ activation of (Na+K+)-ATPase in bulk isolated glial cells and synaptosomes of epileptogenic cortex. Brain Res 261: 75–85

    Article  PubMed  CAS  Google Scholar 

  27. Gusella JF, Wexler NS, Conneally PM et al. (1983) A polymorphic DNA marker genetically linked to Huntington’s disease. Nature 306: 234–238

    Article  PubMed  CAS  Google Scholar 

  28. Gusella JF, Tanzi RE, Anderson MA, Hobbs W, Gibbons K, Raschtchian R, Gilliam TC, Wallace M, Wexler NS, Conneally PM (1984) DNA markers for nervous system disease. Science 225: 1320–1326

    Article  PubMed  CAS  Google Scholar 

  29. Haldane JBS, Smith CAB (1974) A new estimate of linkage between the genes for color blindess and haemophilia in man. Ann Engen 14: 10–31

    Article  Google Scholar 

  30. Harper PS, Rivas ML, Bias WB, Hutchinson JR, Dyken PR, McKusick VA (1972) Genetic linkage confirmed between the locus for myotonic dystrophy and the ABH secretion and Lutheran blood group loci. Am J Hum Genet 24: 310

    PubMed  CAS  Google Scholar 

  31. Hartung E (1920) Zwei Fälle von Paramyoclonus multiplex mit Epilepsie. Z Gesamte Neurol Psychiatr 56: 151–153

    Article  Google Scholar 

  32. Herpin TH (1852) Du pronostic et traitement curatif de l’épilepsie. Ouvrage couronné par l’institut de France en 1850, 2 p 1, 622 pp. Paris, Baillière

    Google Scholar 

  33. Hodge SE, Anderson CE, Neiswanger K et al. (1983) The search for heterogeneity in insulin dependent diabetes mellitus (IDDM): linkage studies, two locus models, and genetic heterogeneity. Am J Hum Genet 35: 1139–1155

    PubMed  CAS  Google Scholar 

  34. Hunt JR (1921) Dyssynergia cerebellaris myoclonica - Primary atrophy of the dentate system: a contribution to the pathology and symptomatology of the cerebellum. Brain 44: 490538

    Google Scholar 

  35. Iadorola MJ, Gale K (1982) Substantia nigra: site of anticonvulsant activity mediated by yaminobutyric acid. Science 218: 1237–1240

    Article  Google Scholar 

  36. Jackson JF, Currier RD, Terasaki PI, Morton NE (1977) Spinocerebellar ataxia and HLA linkage. N Engl J Med 296: 11–38

    Article  Google Scholar 

  37. Janz D (1982) In tema di remissione e di ricomparsa di crisi durante e dopo il trattamento farmacologico dell’epilessia. Boll Lega Ital Epil 39: 95–100

    Google Scholar 

  38. Janz D (1985) Epilepsy with impulsive petit mal (Juvenile myoclonic epilepsy). Acta Neurol Scand 72: 449–459

    Article  PubMed  CAS  Google Scholar 

  39. Janz D, Christian W (1957) Impulsiv-petit mal. Dtsch Z Nervenheilk 19: 155–182

    Google Scholar 

  40. Janz D, Kern A, Mössinger HJ, Puhlmann HU (1982) Rückfallprognose während und nach Reduktion der Medikamente bei Epilepsiebehandlung. In: Remschmidt H, Rentz R, Jungmann J (eds) Epilepsie 1981. Thieme, Stuttgart, pp 311–318

    Google Scholar 

  41. King JO (1975) Progressive myoclonic epilepsy due to Gaucher’s disease in an adult. J Neurol Neurosurg Psychiatry 38: 849–854

    Article  PubMed  CAS  Google Scholar 

  42. Klein J (1979) The major histocompatibility complex of the mouse. Science 203: 516

    Article  PubMed  CAS  Google Scholar 

  43. Koskiniemi M, Toivakka E, Donner M (1974) Progressive myoclonus epilepsy, electroencephalographic findings. Acta Neurol Scand 50: 333–359

    Article  PubMed  CAS  Google Scholar 

  44. Lafora GR, Glueck B (1911) Contributions to the histopathology and pathogenesis of myoclonic epilepsy. Bull Gov Hosp Insane 3: 96

    Google Scholar 

  45. Lamman LU, Olaisen B (1985) Report of the committee on the genetic constitution of chromosome six. Cytogenet Cell Genet 31: 129–155

    Google Scholar 

  46. Lennox WG, Lennox MA (1960) Epilepsy and related disorders. Little Brown, Boston

    Google Scholar 

  47. Lundborg H (1912) Der Erbgang der progressiven Myoklonusepilepsie. Z Gesamte Neurol Psychiatr 9: 353–358

    Article  Google Scholar 

  48. Matthes A (1969) Genetic studies in epilepsy. In: Gastaut H, Jasper H, Bancaud J, Waltregny A (eds) The physiopathogenesis of the epilepsies. Thomas, Springfield, pp 26–30

    Google Scholar 

  49. Matthes A, Weber H (1968) Klinische und elektroenzephalographische Familienuntersuchungen bei Pyknolepsien. Dtsch Med Wochenschr 93: 429–435

    Article  PubMed  CAS  Google Scholar 

  50. McKusick VA (1983) Mendelian inheritance in man. In: Catalogs of autosomal dominant, autosomal recessive and X-linked phenotypes, 5th edn. John Hopkins University Press, Baltimore

    Google Scholar 

  51. McKusick VA (1986) Mapping the human genome: status, interpretation and prospects. 7th International Congress of Human Genetics, Berlin, abstracts vol 1, no 12

    Google Scholar 

  52. Metrakos K, Metrakos JD (1961) Genetics of convulsive disorders. II. Genetic and electroencephalographic studies in centrencephalic epilepsy. Neurology (Minn) 11: 474–483

    Google Scholar 

  53. Mohr J (1954) A study of linkage in man. Munksgaard, Copenhagen

    Google Scholar 

  54. Monaghan HP, O’Sullivan M, O’Donohoe NV (1982) HLA antigens and cryptogenic myoclonic epilepsy. J Med Sci 151 (6): 188–189

    CAS  Google Scholar 

  55. Morton ME (1962) Segregation and linkage. In: Burdette (ed) Methodology in human genetics. Holden Day, San Francisco, pp 17–52

    Google Scholar 

  56. Narahashi T (1986) Modulators acting on sodium and calcium channels: Patch clamp analysis. Delgado-Escueta AV, Ward AA Jr, Woodbury DM, Porter RJ (eds) Advances in neurology, vol 44. Raven, New York, pp 211–225

    Google Scholar 

  57. Noebels JL (1979) Analysis of inherited epilepsy using single locus mutations in mice. Fed Proc 38: 2405–2410

    PubMed  CAS  Google Scholar 

  58. Noebels JL (1982) Defined gene models of the inherited epilepsies. In: Anderson VE, Hauser WA, Penry JK, Sing CF. Genetic basis of the epilepsies. New York, pp 211–224

    Google Scholar 

  59. Olsen RW, Snowmen AM, Lee R, Lomax P, Wamsley JK (1984) Role of the y-aminobutyric acid receptor/ionophore complex in seizure disorders. Ann Neurol 16 (S): 90–95

    Article  Google Scholar 

  60. Ott J (1977) Counting methods (EM algorithm) in human pedigree analysis. Ann Hum Genet 40: 443–454

    PubMed  CAS  Google Scholar 

  61. Ounsted C (1952) The factor of inheritance in convulsive disorders in childhood. Proc Soc Med 45: 865–868

    CAS  Google Scholar 

  62. Overweg J, Rowan AJ, Binnie CD, Nagelkerke NJD, Costing J (1981) Prediction of seizure recurrence after withdrawal of antiepileptic drugs. In: Dam M, Gram L, Penry JK (eds) Advances in epileptology: 12th epilepsy international symposium. Raven, New York, pp 503–508

    Google Scholar 

  63. Pedersen HE, Krogh E (1970) Decentraliseret behandling og kontrol of patienter med epilepsi. Nord Med 83: 689–694

    PubMed  CAS  Google Scholar 

  64. Penry JK, Porter R, Dreifuss FE (1975) Simultaneous recordings of absence seizures with videotape and EEG. Brain 98: 427–440

    Article  PubMed  CAS  Google Scholar 

  65. Pericak-Vance MA, Conneally PM, Merritt AD, Roos R, Vance JM, Yu PL, Norton JA, Angel JP (1979) In: Chase TMN, Wexler NS, Barbeen A (eds) Advances in neurology. Raven, New York, p 59

    Google Scholar 

  66. Pericak-Vance MA, Stajich JM, Conneally PM, Vance J, Herbstreith MH, Roses AD (1983) Genetic linkage analysis of myotonic dystrophy with the complement component 3 (C3), secretor (Se), and Lewis (Le) loci on chromosome 19. Program abstracts, 7th International Human Gene Mapping Workshop, University of California at Los Angeles, 21–26 Aug 1983

    Google Scholar 

  67. Phillips JA, Hjelle BL, Seeburg PH, Zachmann M (1981) Molecular basis for familial isolated growth hormone deficiency. Proc Natl Acad Sci USA 78: 6372–6375

    Article  PubMed  CAS  Google Scholar 

  68. Rabot M (1899) De la myoclonie épileptique. Thesis, Paris

    Google Scholar 

  69. Rapport RL II, Harris AB, Friel PN, Ojemann GA (1975) Human epileptic brain Na+K+ -ATPase activity and phenytoin concentrations. Arch Neurol 32: 549–554

    Article  PubMed  Google Scholar 

  70. Rigby PW, Dieckmann M, Rhodes C, Berg P (1977) Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I. J Mol Biol 113 (1): 237–251

    Article  PubMed  CAS  Google Scholar 

  71. Rimoin DL, Metrakos JD (1964) The genetics of convulsive disorders in the families of hemiplegics. Proc 2nd Int Congr Hum Genet 3: 1655–1658

    Google Scholar 

  72. Rivas ML (1983) Genetic analysis of petit mal epilepsy I. Evaluation of HLA, blood groups, serum proteins, and red cell enzymes. Epilepsia 24: 115

    Google Scholar 

  73. Roses AD, Pericak-Vance MA, Yamaoka LH (1983) Recombinant DNA strategies in genetic neurological diseases. In: Austin L, Jeffrey PL (eds) Molecular aspects of neurological diseases. Academic, Sydney, pp 3–16

    Google Scholar 

  74. Sarfarazi M, Ball S, O’Brien T, Davies K, Shaw D, Harper PS (1983) Myotonic dystrophy and markers on chromosome 19. Program abstracts, 7th International Human Gene Mapping Workshop, University of California at Los Angeles, 21–26 Aug 1983

    Google Scholar 

  75. Seyfried TN (1982) Developmental genetics of audiogenic seizure susceptibility in mice. In: Anderson VE, Hauser WA, Penry JK, Sing CF (eds) Genetic basis of the epilepsies. Raven, New York, pp 199–210

    Google Scholar 

  76. Seyfried TN, Glaser GH, Yu RK, Palayoor ST (1986) Inherited convulsive disorders in mice. In: Delgado-Escueta AV, Ward AA Jr, Woodbury DM, Porter RJ (eds) Advances in neurology, vol44. Raven, New York, pp 115–135

    Google Scholar 

  77. Shows TB, Sakaguchi AY, Naylor SL (1982) Mapping the human genome, cloned genes, DNA polymorphisms and inherited disease. Adv Hum Genet 12: 341–353

    Google Scholar 

  78. Shows TB, McAlpine PV, Miller RL (1983) The 1983 catalogue of mapped human genetic markers and report of the nomenclature committee. Cytogenet Cell Genet 37: 340–393

    Article  Google Scholar 

  79. Skolnick MH, White R (1982) Strategies for detecting and characterizing restriction fragment length polymorphisms (RFLPs) Cytogenet Cell Genet 32: 58–67

    PubMed  CAS  Google Scholar 

  80. Southern EM (1975) Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol 98: 503–517

    Article  PubMed  CAS  Google Scholar 

  81. Stanburg J, Wyngaarden JB, Fredrickson DS, Goldstein JL, Brown MS (eds) (1983) Metabolic basis of inherited diseases. McGraw-Hill, New York, chap 3, p 79

    Google Scholar 

  82. Terasaki PI (ed) (1980) Histocompatibility testing. UCLA tissue typing laboratory 1980

    Google Scholar 

  83. Tower DB (1965) Problems associated with studies of electrolyte metabolism in normal and epileptogenic cerebral cortex. Epilepsia 6: 183

    Article  PubMed  CAS  Google Scholar 

  84. Tsuboi T (1980) Genetic aspects of epilepsy. Folia Psychiatr Neurol Jpn 34: 215–225

    PubMed  CAS  Google Scholar 

  85. Tsuboi T, Christian W (1973) On the genetics of primary generalized epilepsy with sporadic myoclonias of the impulsive petit mal type: A clinical and electroencephalographic study of 399 probands. Humangenetik 19: 155–182

    PubMed  CAS  Google Scholar 

  86. Tsuboi T, Endo S (1977) Incidence of seizures and EEG abnormalities among offspring of epileptic patients. Hum Genet 36: 173–189

    Article  PubMed  CAS  Google Scholar 

  87. Tudor I, Milea S, Bicescu E, Ivana D (1973) Catamnestic study of childhood epilepsy. Rev Roum Neurol 10: 341–352

    PubMed  CAS  Google Scholar 

  88. Unverricht H (1891) Die Myoklonie. Deuticke, Leipzig

    Google Scholar 

  89. Vogel F, Motulsky AG (1979) Human genetics: Problems and approaches. Springer, Berlin Heidelberg New York

    Google Scholar 

  90. Ward RH (1982) Genetics and epidemiology: a fruitful interface for the study of epilepsy. In: Anderson VE, Hauser WA, Penry JK, Sing CF (eds) Genetic basis of the epilepsies. Raven, New York, pp 317–332

    Google Scholar 

  91. Weinstock GM, Rhys C, Berman ML, Hampar B, Jackson D, Silhary TJ, Weisemann J, Zweig M (1983) Open reading frame expression vectors: a general method for antigen production in Escherichia coli using protein fusions to beta-galactosidase. Proc Natl Acad Sci USA 80 (14): 4432–4436

    Article  PubMed  CAS  Google Scholar 

  92. White PC, New MI, Dupont B (1984) HLA linked congenital adrenal hyperplasia results from defective gene encoding a cytochrome P-450 specific for 21-hydroxylation. Proc Natl Acad Sci USA 81: 7505–7509

    Article  PubMed  CAS  Google Scholar 

  93. White PC, Grossberger D, Onufer B, Chaplin D, New MI, Dupont B, Strominger JL (1985) Two genes encoding steroid 21-hydroxylase are located near the genes encoding the fourth component of complement in man. Proc Natl Acad Sci USA 82: 1089–1093

    Article  PubMed  CAS  Google Scholar 

  94. White R (1984) Looking for epilepsy genes. Ann Neurol 16 [Suppl] 2: 12–17

    CAS  Google Scholar 

  95. Wyman AR, White R (1980) A highly polymorphic locus in human DNA. Proc Natl Acad Sci USA 77: 6754–6758

    Article  PubMed  CAS  Google Scholar 

  96. Zatz M, Vianna-Morgante AM, Campos P, Diament AJ (1981) Translocation (X:6) in a female with Duchenne muscular dystrophy: Implications for the localization of the DMD locus. J Med Genet 19: 442

    Google Scholar 

  97. Zeman W (1976) The neuronal ceroid-lipo fuscinoses. In: Zimmerman HM (ed) Progress in neuropathology, vol 3. Grune and Stratton, Orlando, pp 203–223

    Google Scholar 

  98. Zeman W, Donahue S, Dyken P, Green J (1970) The neuronal ceroidlipofuscinoses (Batten-Vogt syndrome). In: Vinken PJ, Bruyn GW (eds) Handbook of neurology, vol 10. North-Holland, Amsterdam, pp 588–679

    Google Scholar 

Download references

Author information

Author notes

  1. D. A. Greenberg

    Present address: Department of Psychiatry, Mt. Sinai Medical Center, 1 Gustave Levy Place, New York, NY, 10029, USA

Authors and Affiliations

  1. Reed Neurological Research Center, UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, CA, 90024, USA

    A. V. Delgado-Escueta & L. Treiman

  2. Southwest Regional VA Epilepsy Center, Neurology Service, Wadsworth VA Medical Center, Los Angeles, USA

    D. A. Greenberg

Authors
  1. A. V. Delgado-Escueta
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. A. Greenberg
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. L. Treiman
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Neurologische Abteilung, Universitätsklinikum Rudolf Virchow, Freie Universität Berlin, Spandauer Damm 130, D-1000, Berlin 19, Germany

    Gertrud Beck-Mannagetta M.D. (Assistant Professor of Neurology) & Dieter Janz M.D. (Professor of Neurology) (Assistant Professor of Neurology) &  (Professor of Neurology)

  2. Dight Laboratories, University of Minnesota, 400 Church Street S.E., 55455, Minneapolis, MN, USA

    V. Elving Anderson M.D. (Professor of Genetics and Cell Biology) (Professor of Genetics and Cell Biology)

  3. Abteilung für Neuropädiatrie, Universität Kiel, Schwanenweg 20, D-2300, Kiel, Germany

    Hermann Doose M.D. (Professor of Pediatrics) (Professor of Pediatrics)

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Delgado-Escueta, A.V., Greenberg, D.A., Treiman, L. (1989). Perspectives: Clues in Mapping Epilepsy Genes. In: Beck-Mannagetta, G., Anderson, V.E., Doose, H., Janz, D. (eds) Genetics of the Epilepsies. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-95553-2_24

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-95553-2_24

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-95555-6

  • Online ISBN: 978-3-642-95553-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation