Virus Investigations in Heart Muscle Disease

  • P. Morgan-Capner
  • P. J. Richardson
  • C. McSorley
  • K. Daly
  • J. R. Pattison


There is substantial evidence available for the involvement of viruses in the aetiology of heart muscle disease. Many viruses have been implicated (Lansdown 1978) but the enteroviruses have been most frequently associated, particularly in relation to myocarditis and congestive cardiomyopathy.


Vero Cell Acute Myocarditis Neutralization Antibody Titre Enterovirus Infection Neutralization Titre 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Anderson JL, Carquist JF, Hammond EH (1982) Deficient natural killer cell activity in patients with idiopathic dilated cardiomyopathy. Lancet II: 1124–1127CrossRefGoogle Scholar
  2. Anderson MJ, Davis LR, Jones SE, Pattison JR, Serjeant GR (1982) The development and use of an antibody capture radioimmunoassay for specific IgM to a human parvovirus-like agent. J Hyg 88: 309–324CrossRefGoogle Scholar
  3. Bolte H-D, Schultheiss P (1978) Immunological results in myocardial diseases. Postgrad Med J 54: 500–503PubMedCrossRefGoogle Scholar
  4. Burch GE, Sun S-C, Colclough HL, Sohal RS, De Pasquale NP (1967) Coxsackie B viral myocarditis and valvulitis identified in routine autopsy specimens by immunofluorescent techniques. Am Heart J 74: 13–23PubMedCrossRefGoogle Scholar
  5. Burch GE, Sun S-C, Chu KC, Sohal RS, Colclough HL (1968) Interstitial and coxsackievirus B myocarditis in infants and children. JAMA 203: 55–62CrossRefGoogle Scholar
  6. Cambridge G, MacArthur CGC, Waterson AP, Goodwin JF, Oakley CM (1979) Antibodies to Coxsackie B viruses in congestive cardiomyopathy. Br Heart J 41: 692–696PubMedCrossRefGoogle Scholar
  7. Clinicopathological Conference (1980) A case of congestive cardiomyopathy Br Med J I: 613–619Google Scholar
  8. Cradock-Watson JE, Ridehalgh MKS, Anderson MJ, Pattison JR (1981) Outcome of asymptomatic infection with rubella virus during pregnancy. J Hyg 87: 147–154CrossRefGoogle Scholar
  9. Daly K, Richardson PJ, Olsen EGJ, Pattison J, Jackson G, Jewitt DE (1981) Immunosuppressive therapy in acute inflammatory myocarditis. Circulation 64 [Suppl IV] 27Google Scholar
  10. Dörries R, ter Meulen V (1980) Detection of enterovirus specific IgG and IgM antibodies in humans by an indirect solid phase radioimmunoassay. Med Microbiol Immunol 168: 159–171PubMedCrossRefGoogle Scholar
  11. El-Hagrassy MMO, Banatvala JE, Coltart DJ (1980) Coxsackie-B-virus-specific IgM responses in patients with cardiac and other diseases. Lancet II: 1160–1162CrossRefGoogle Scholar
  12. Feinstone S, Hensley GT, Rytel MW (1973) PostCoxsackievirus B3 myocardiopathy in mice. Proc Soc Exp Biol Med 144: 345PubMedGoogle Scholar
  13. Flehmig B, Ranke M, Berthold H, Gerth J-J (1979) A solid phase radioimmunoassay for detection of IgM antibodies to hepatitis A virus. J Infect Dis 140: 169–175PubMedCrossRefGoogle Scholar
  14. Fowles RE, Bieber CP, Stinson EB (1979) Defective in vitro suppressor cell function in idiopathic congestive cardiomyopathy. Circulation 59: 483–491PubMedGoogle Scholar
  15. Grist NR, Bell EJ (1974) A six-year study of coxsackievirus B infections in heart disease. J Hyg 73: 165–172CrossRefGoogle Scholar
  16. Grist NR, Bell EJ, Assaad F(1978) Enteroviruses in human disease. In: Melnick JL (ed) Progress in medical virology, vol 24. Karger, Basel, pp 114–157Google Scholar
  17. Huber SA, Job LP, Woodruff JF (1980) Lysis of infected myofibers by Coxsackievirus B-3-immune T lymphocytes. Am J Pathol 98: 681–694PubMedGoogle Scholar
  18. Huber SA, Job LP, Woodruff JF (1981) Sex-related differences in the pattern of Coxsackievirus B-3-induced immune spleen cell cytotoxicity against virus-infected myofibers. Infect Immun 32: 68–73PubMedGoogle Scholar
  19. Katze MG, Crowell RL (1980) Indirect enzyme-linked immunosorbent assay (ELISA) for the detection of coxsackievirus group B antibodies. J Gen Virol 48: 225–229PubMedCrossRefGoogle Scholar
  20. Lansdown ABG (1978) Viral infections and diseases of the heart. In: Melnick JL (ed) Progress in medical virology 24. Karger, Basel, pp 70–113Google Scholar
  21. Lerner AM, Wilson FM (1973) Virus myocardiopathy. In: Melnick JL (ed) Progress in medical virology 15. Karger, Basel, pp 63–91Google Scholar
  22. Levin S (1980) Parvovirus: a possible etiologic agent in cardiomyopathy and endocardial fibroelastosis. Hum Pathol 11: 404–405PubMedCrossRefGoogle Scholar
  23. Mac William KM, Cooper MA (1974) Antibody levels in human sera measured by the fluorescent antibody technique against the Coxsackie B viruses type 1–5 grown in HEp 2 cells compared with the results obtained by neutralization. J Clin Pathol 27: 825–827CrossRefGoogle Scholar
  24. Minor TE, Helstron PB, Nelson DB, D’Alessio DJ (1979) Counterimmunoelectrophoresis test for immunoglobulin M antibodies to group B coxsackievirus. J Clin Microbiol 9: 503–506PubMedGoogle Scholar
  25. Morgan-Capner P, McSorley C, Pattison JR (1983) Antibody capture radioimmunoassay (MAC-RIA) for coxsackievirus B4 and B5-specific IgM. J Hyg 90: 333–349CrossRefGoogle Scholar
  26. Mortimer PP, Tedder RS, Hambling MH, Shafi MS, Burkhardt F, Schilt U (1981) Antibody capture radioimmunoassay for anti-rubella IgM. J Hyg 86: 139–153CrossRefGoogle Scholar
  27. Pattison JR, Dane DS, Mace JE (1975) Persistence of specific IgM after natural infection with rubella virus. Lancet 1: 185PubMedCrossRefGoogle Scholar
  28. Richardson PJ (1974) King’s endomyocardial bioptome. Lancet I: 660–661CrossRefGoogle Scholar
  29. Robinson JA, O’Connell JB, Roeges LM, Major EO, Gunnar RM (1981) Coxsackie B3 myocarditis in athymic mice. Proc Soc Exp Biol Med 166: 80–91PubMedGoogle Scholar
  30. Schmidt NJ, Lennette EH, Dennis J (1968) Characterization of antibodies produced in natural and experimental coxsackievirus infections. J Immunol 100: 99–106PubMedGoogle Scholar
  31. Schmidt NJ, Magoffin RL, Lennette EH (1973) Association of group B coxsackieviruses with cases of pericarditis, myocarditis or pleurodynia by demonstration of immunoglobulin M antibody. Infect Immun 8: 341–348PubMedGoogle Scholar
  32. Smith WG (1970) Coxsackie B myopericarditis in adults. Am Heart J 80: 34–46PubMedCrossRefGoogle Scholar
  33. Takatsu T, Kitamura Y, Monita H, Deguchi M, Imomura I, Kawamura K (1980) Viral myocarditis and cardiomyopathy. In: Sekiguchi M, Olsen EGJ (eds) Cardiomyopathy - clinical, pathological and theoretical aspects. University of Tokyo Press Tokio, pp 341–363Google Scholar
  34. Wilfert CM, Buckley RH, Mohanakumar T, Griffith JF, Katz SL, Whisnant JK, Eggleston PA, Moore M, Treadwell E, Oxman MN, Rosen FS (1977) Persistent and fatal central-nervous-system echovirus infections in patients with agammaglobulinaemia. N Engl J Med 296: 1485–1489PubMedCrossRefGoogle Scholar
  35. Wilson FM, Miranda QR, Chasen JL, Lerner AM (1969) Residual pathological changes following murine Coxsackie A and B myocarditis. Am J Pathol 55: 253–262PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1984

Authors and Affiliations

  • P. Morgan-Capner
  • P. J. Richardson
  • C. McSorley
  • K. Daly
  • J. R. Pattison

There are no affiliations available

Personalised recommendations