Uptake of Serum Lipoproteins into the Arterial Wall
It is well-known that serum low-density lipoproteins (LDL) and very low-density lipoproteins (VLDL) play an important role in the development of atherosclerosis. High-density lipoproteins (HDL) are considered antiatherogenic. Fluorescent antibody techniques indicate that in thoracic aorta from normal rabbits LDL cannot be identified. In rabbits receiving a diet containing 1% cholesterol, LDL can be clearly identified in the intima. This evidence suggests that serum LDL enters the arterial wall of the hyperlipidemic rabbit.
KeywordsArterial Wall Atherosclerotic Lesion Foam Cell Cholesterol Ester Serum Lipoprotein
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