Cholesterol Metabolism in High- and Low-Responding Rhesus Monkeys
The response of serum cholesterol to dietary cholesterol varies not only among species of animals but also among individuals of the same species. The rhesus monkey is no exception to this phenomenon (Eggen, 1976). Thus, when we fed a high-cholesterol diet which provided saturated fat at 40% of calories and cholesterol at 1 mg/kcal to 36 young male rhesus monkeys, they developed hypercholesterolemia with serum cholesterol levels distributed essentially normally but with large variability. The mean serum cholesterol for the 36 animals was 431 ± 137 (S.D.) mg/dl, whereas the mean for individual animals ranged from 151 to 721 mg/dl.
KeywordsSerum Cholesterol Basal Diet Dietary Cholesterol Neutral Steroid Hepatic Cholesterol Synthesis
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