Connective Tissue in Atherosclerosis
In introducing the subject of the workshop on “Connective Tissues in Atherosclerotic Lesions” he chaired in September, 1975, at the International Workshop — Conference on Atherosclerosis at London, Ontario, Canada, Dr. Robert More, paraphrased the importance of connective tissues in atherosclerotic lesions by stating: “No connective tissue, no serious disease.” (More, 1976) This reminder was no doubt necessitated by the circumstance that for several decades the investigators concerned with atherosclerosis were preoccupied with lipids which overshadowed every other aspect of the disease and the underlying lesions. Yet, the connective tissue is the most prominent and clinically important component of the atherosclerotic lesions, particularly those in the medium size arteries, such as the coronary and cerebral vessels; it is this ever-enlarging component of the lesions that is responsible for the encroachment upon the lumen and the ensuing consequences.
KeywordsSmooth Muscle Cell Hyaluronic Acid Atherosclerotic Lesion Basal Lamina Elastic Tissue
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