Electroimmunoassays of Serum Apolipoproteins in Normolipidemic Subjects and Patients with Primary Hyperlipoproteinemias
A number of studies from this and other laboratories have demonstrated the protein heterogeneity of all major density lipoprotein classes of human serum (Alaupovic et al., 1972; Blum and Levy, 1975). These findings led to the concept (Alaupovic et al., 1972) of lipoprotein families as the fundamental physicochemical components of the serum lipoprotein system. The lipoprotein family concept is based on apolipoproteins as the only distinct chemical markers by which lipoproteins may be identified and differentiated. At the present time, this concept recognize the existence of five lipoprotein families, each of which is characterized by the exclusive presence of a single apolipoprotein: lipoprotein family A (LP-A) is characterized by the presence of apolipoprotein A (apoA or its constitutive A-I and A-II polypeptides), lipoprotein B (LP-B) by apolipoprotein B (apoB), lipoprotein C (LP-C) by apolipoprotein C (apoC or its constitutive C-I, C-II, and C-III polypeptides), lipoprotein D (LP-D) by apolipoprotein D (apoD or “thin-line” polypeptide), and lipoprotein E by apolipoprotein E (apoE or “arginine-rich” polypeptide).
KeywordsExclusive Presence Serum Apolipoprotein Monospecific Antiserum NORMOLIPIDEMIC Subject Lipoprotein Family
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