Current Concepts of Hyperlipoproteinemia
In discussing the current concepts of hyperlipoproteinemia, let me begin with the most basic definitions. First, the term hyperlipidemia is used to describe a condition in which the concentration of one or more of the plasma lipids, usually cholesterol or triglyceride, is elevated above normal limits. All definitions of hyperlipidemia are necessarily arbitrary. What is usually meant by a “normal” cholesterol or triglyceride, as reported from a clinical laboratory, is a statistical normal. This does not necessarily represent a safe or optimal or desirable level of the plasma lipid. Table 1 shows a list of arbitrarily chosen cutoff values for defining overt hyperlipidemia currently employed in the Lipid Clinic of The Methodist Hospital. There is no absolute cutoff point for either plasma cholesterol or triglyceride which divides the entire population into normal and abnormal groups.
KeywordsGlycogen Storage Disease Familial Hypercholesterolemia Acute Intermittent Porphyria Methodist Hospital Abnormal Lipoprotein
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