Comparison of Methods of Plasma Triglyceride Turnover
Over the past several years, a kinetic approach has been widely used in an attempt to determine whether either overproduction or impaired removal of very low-density lipoproteins (VLDL) is the fundamental mechanism underlying the elevated triglyceride (TG) levels seen in many primary and secondary hyperlipidentic states. No method of measuring TG or VLDL turnover has gained universal acceptance since none has been adequately validated. Therefore, a comparison of data between studies is often difficult, and conflicting conclusions have been claimed as to the prime mechanism of the TG elevation in endogenous hypertriglyceridemia (Farguhar et al., 1965; Bierman et al., 1970; Boberg et al., 1972; Havel et al., 1970). In addition to methodologic considerations, differences in results and conclusions may partly be accounted for by marked differences in patient selection and heterogeneity of subjects studied.
KeywordsFractional Catabolic Rate Plasma Glycerol Lipolytic Rate Iodine Monochloride Large VLDL
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