Abstract
For more than half a century prolonged adrenergic stimulation has been known to be an important determinent of the outcome of acute critical illness. In shock of various etiologies in man and animals there is a negative correlation between the catecholamine blood levels and survival. Further, an infusion of catecholamines in amounts that can be produced endogenously during critical illness will result in shock and death in animals, the lungs showing the characteristic changes of “shock lung”. Conversely, animals made tolerant to epinephrine will withstand lethal doses of epinephrine and endotoxin as well als lethal periods of hemorrhagic shock.
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References
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Berk, J.L. (1974). Microcirculatory Effects of Epinephrine with Alterations by Alpha and Beta Adrenergic Blockade. In: Ahnefeld, F.W., Burri, C., Dick, W., Halmágyi, M. (eds) Mikrozirkulation. Klinische Anästhesiologie und Intensivtherapie, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-95268-5_15
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DOI: https://doi.org/10.1007/978-3-642-95268-5_15
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