Abstract
My interests lie in the basic cellular events which control the progression of a cell through a division cycle, the events which get cells from G 0 into G 1, G 1 into S, S into G 2 and G 2 into M (Fig. 1). For some years we have been concentrating on the last of these, the study of the essential requirements of a post S-phase cell which allow it to enter mitosis, i.e. we are concerned with the significance of the G 2 interval in mammalian cells. Any treatment, physical or chemical, which alters the progression of cells through G 2 and mitosis is potentially of interest in helping to analyse the rate-limiting (control) mechanisms. Adriamycin (Ad) and daunomycin (Da) come into this category.
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© 1972 Springer-Verlag, Berlin Heidelberg
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Wheatley, D.N. (1972). Action of Adriamycin on HeLa Cells. Evidence of a G2 Inhibition. In: Carter, S.K., Marco, A.D., Ghione, M., Krakoff, I.H., Mathé, G. (eds) International Symposium on Adriamycin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-95227-2_6
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DOI: https://doi.org/10.1007/978-3-642-95227-2_6
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