Skip to main content
SpringerLink
Log in

Pathologie der Hypophysentumoren

Pathology of Pituitary Tumors

  • Chapter
Book cover Oestrogene Hypophysentumoren

Part of the book series: Oestrogene Hypophysentumoren ((ENDOKRINOLOGIE,volume 15))

Summary

We refer to the frequent occurence of subclinical hyperplasias or microadenomas in the distal lobe of the pituitary whose size does vary very much. 10% of the intracranial tumours belong to the volume-taking adenomas. Their various extension-possibilities are described. It is noted that the individual strongly marked variation of the anatomical details in the hypophysis region influence the symptomatology of the adenomas.

The histological diagnosis based on hitherto existing staining methods does not give justice to the clinical reality. It is possible by aid of cytochemical methods to classify the adenomas in accordance with clinical statements; either into endocrine-active or endocrine-inactive groups, of which the so called eosinophilic and basophilic adenomas show extreme variances of the active group.

The idea known up to present times that practically no volume-taking basophilic adenomas exist is contradictory. Adenomas proved by histochemical methods give evidence that their cells contain substrate-complexes at changeable frequency which are responsible for the secretion of gonado-thyreotropic hormones.

We come to the conclusion that probably the tumourgrowth caused by interruption of the hypothalamic influence does transform the histological picture and, consequently also the functional behaviour of the adenomas in the sense of an inactivity for which also the distribution of age of both adenoma-groups is responsible, to wit the active group at the age peak of 35–40 and the inactive group at the age between 55–60 years.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 59.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 79.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Adams, C. W. M., and K. V. Swettenham: The histochemical identification of two types of basophile cell in the normal human adenohypophysis. J. Path. Bact. 75, 95–103 (1958).

    Article  PubMed  CAS  Google Scholar 

  • Backus, M.-L.: Untersuchungen zur Statistik der Biologie und Pathologie intrakranieller und spinaler raumfordernder Prozesse. Inaug.-Diss. Med. Fak. Köln, 1965.

    Google Scholar 

  • Bailey, O. T., and E. C. Cutler: Malignant adenomas of the chromophobe cells of the pituitary body. Arch. Path. 29, 268–399 (1940).

    Google Scholar 

  • Bailey, P., and H. Cushing: Studies in Acromegaly. VII. The microscopical structure of the adenomas in acromegalic dyspituitarism (Fugitive acromegaly). Amer. J. Path. 4, 545–563 (1928).

    PubMed  CAS  Google Scholar 

  • Bakay, L.: The results of 300 pituitary adenoma operations (Prof. Herbert Olivecrona’s series). J. Neurosurg. 7, 240–255 (1950).

    Article  PubMed  CAS  Google Scholar 

  • Barrnett, J. R., and A. M. Seligman: Histochemical demonstration of sulfhydryl and disulfide groups of protein. J. nat. Cancer Inst. 14, 769–799 (1954).

    PubMed  CAS  Google Scholar 

  • Banda, C.: Über den normalen Bau und einige pathologische Veränderungen der menschlichen Hypophysis cerebri. Arch. Anat. Physiol. 1900, 373–380.

    Google Scholar 

  • Banda, C. E. Stadelmann u. A. Fraenkel: Klinische und anatomische Beiträge zur Lehre von der Akromegalie. Dtsch. med. Wschr. 27, 513, 536, 564 (1901).

    Google Scholar 

  • Bergerhoff, W.: Die Sella turcica im Röntgenbild. Beitr. Neurochir. H. II, Leipzig: Johann Ambrosius Barth 1960.

    Google Scholar 

  • Braun, W., u. T. Tzonos: Über ein ungewöhnlich rasch wachsendes Hypophysencarcinom mit intracerebralen Metastasen. Acta neurochir. (Wien) 12, 615–624 (1964).

    Article  Google Scholar 

  • Bull, J.: The normal variations in the position of the optic recess of the third ventricle. Acta radiol. (Stockh.) 46, 72–80 (1956).

    Article  CAS  Google Scholar 

  • Burt, A. S., and J. T. Velardo: Cytology of human adenohypophysis as related to bioassays for tropic hormones. J. clin. Endocr. 14, 979–996 (1954).

    Article  PubMed  CAS  Google Scholar 

  • Busch, W.: Die Morphologie der Sella turcica und ihre Beziehung zur Hypophyse. Virchows Arch. path. Anat. 320, 437–458 (1951).

    Article  CAS  Google Scholar 

  • Conn, H. J.: Biological stains. 6th edit. Geneva, New York: Biotech. Publications 1953.

    Google Scholar 

  • Costello, R. T.: Subclinical adenoma of pituitary gland. Amer. J. Path. 12, 205–216 (1936).

    PubMed  CAS  Google Scholar 

  • Costero, J.: Some problems related to the origin and meaning of pituitary gland tumors. Arch. Path. 46, 243–259 (1948).

    PubMed  CAS  Google Scholar 

  • Costero, J., y H. Beredet: Estudio anatómico de 135 tumores de la hipófisis y dell tracto hipofisario. Monogr. Soc. Méd. del Hospital General, México, 1939.

    Google Scholar 

  • Courtellemont, V.: Rapport au XXI Congrès des Aliènistes et Neurologistes de langue française. pp. 14–39. Amiens, 1911.

    Google Scholar 

  • Coxon, R. V.: A case of haemorrhage into a pituitary tumour simulating rupture of an intracranial aneurysm. Guy’s Hosp. Rep. 92, 89–93 (1943).

    Google Scholar 

  • Cruiekshank, B., and A. R. Currie: Localization of tissue antigens with the fluorescent antibody technic: Application to human anterior pituitary hormons. Immunology 1, 13–26 (1958).

    Google Scholar 

  • Cushing, H.: The pituitary body and its disorders. Philadelphia: Lippincott 1912.

    Google Scholar 

  • Cushing, H.: Intracranial Tumours: Notes upon a series of two thousend verified cases with surgical mortality percentages pertraining thereto. Springfield (Ill.): Charles C. Thomas Publ. 1932.

    Google Scholar 

  • Dott, N. M., and P. Bailey: A consideration of the hypophysial adenomata. Brit. J. Surg. 13, 314–366 (1925).

    Article  Google Scholar 

  • Emmart, E. W., S. S. Spicer, and R. W. Bates: Localization of prolactin within the pituitary by specific fluorescent antiprolactin globulin. J. Histochem. 11, 365–373 (1963).

    CAS  Google Scholar 

  • Engels, E. P.: Roentgenographic demonstration of a hypophysial subarachnoid space. Amer. J. Roentgenol. 80, 1001–1104 (1958).

    PubMed  CAS  Google Scholar 

  • Erdheim, J.: Pathologie der Hypophysengeschwülste. Ergebn. Path. 21, 482–561 (1926).

    Google Scholar 

  • Farberow, B. J.: Röntgendiagnostik der Tumoren der Gegend der Sella turcica. Fortschr. Röntgenstr. 50, 445–465 (1934).

    Google Scholar 

  • Fasiani, G. M., F. Columella u. I. Papo: Über Massenblutungen in Hypophysenadenomen. Zbl. Neurochir. 17, 81–92 (1957).

    CAS  Google Scholar 

  • Faulhaber, K. W.: Über basophile Hypophysenadenome. Inaug.-Diss. Med. Fak., Köln 1968.

    Google Scholar 

  • Ferner, H.: Die Beziehungen der Leptomeninx und des Subarachnoidalraumes zur intra-sellären Hypophyse beim Menschen. In: Stoffwechselwirkungen der Steroidhormone. pp. 151–155. Berlin-Göttingen-Heidelberg: Springer 1955.

    Google Scholar 

  • Fisher, A. W. F., and D. Bulmer: Studies of differential staining with acid dyes in the human adenohypophysis. Quart. J. micr. Sci. 105, 467–472 (1964).

    CAS  Google Scholar 

  • Friedmann, G., u. F. Marguth: Intraselläre Liquorcysten. Zbl. Neurochir. 21, 33–41 (1961).

    CAS  Google Scholar 

  • Giordano, A.: Per la storia dell’ acromegalia (prioritá di Andrea Verga nella descrizione del quadro anatomoclinico). R. C. Ist. Lomb. Sc. Lettere-Scienze 74, 129–132 (1941).

    Google Scholar 

  • Glenner, G. G., and R. D. Lillie: Observations on the diazotization-coupling reaction for the histochemical demonstratoin of tyrosine: Metal chelation and formazan variants. J. Histochem. Cytochem. 7, 416–422 (1959).

    Article  PubMed  CAS  Google Scholar 

  • Grant, F. C.: Surgical experience with tumors of pituitary gland. J. Amer. med. Ass. 136, 668–672 (1948).

    Article  CAS  Google Scholar 

  • Graumann, W., u. K. Hinrichsen: Über die Basophilie der cyanophilen Zellen der Hypophyse. Z. Zellforsch. 52, 328–345 (1960).

    Article  PubMed  CAS  Google Scholar 

  • Hanefeld, F.: Hydrolytische Enzyme in Hypophysenadenomen. Histochemie 7, 132–140 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Henderson, W. R.: The pituitary adenomata, a follow-up study of the surgical results in 338 cases (Dr. Harvey Cushing’s series). Brit. J. Surg. 26, 811–921 (1939).

    Article  Google Scholar 

  • Hoffmann, H.: Beitrag zur Frage der Verkalkung in Hypophysenadenomen. Dissertation, Köln 1966.

    Google Scholar 

  • Jefferson, G.: Extrasellar extensions of pituitary adenomas. Proc. Roy. Soc. Med. 33, 433–458 (1948).

    Google Scholar 

  • Jefferson, G.: The invasive adenomas of the anterior pituitary. In: Sherrington Lectures, Nr. Ill, pp. 1–63. Liverpool: Eaton Press 1954.

    Google Scholar 

  • Kay, S., J. K. Lees, and A. P. Stout: Pituitary chromophobe tumors of the nasal cavity. Cancer 3, 695–704 (1950).

    Article  PubMed  CAS  Google Scholar 

  • Kernohan, J. W., and G. P. Sayre: Tumors of the pituitary gland and infundibulum. Atlas of tumor pathology. Sect. X, fasc. 36. Armed Forces Institute of Pathology, Washington D. C., 1956.

    Google Scholar 

  • Konjetzny, G. E.: Eine struma calculosa der Hypophysis. Centralbl. Allg. Path. 22, 338–341 (1911).

    Google Scholar 

  • Kracht, J., u. U. Hachmeister: Hormonbildungsstätten im Hypophysenvorderlappen des Menschen. 15. Symp. Dtsch. Ges. Endokrinol. Berlin-Heidelberg-NewYork: Springer 1969.

    Google Scholar 

  • Kraus, E. J.: Die Hypophyse. In: Handb. d. spez. path. Anatomie, pp. 810–950. Bd. 8, Berlin: Springer 1926.

    Google Scholar 

  • Landing, B. H.: Histologic study of the anterior pituitary gland. A compilation of procedures. Lab. Invest. 3, 348–368 (1964).

    Google Scholar 

  • Launois, P. E.: Recherches sur la glande hypophysare de l’homme. Thèse Fac. Sci. Paris 1904.

    Google Scholar 

  • Marguth, F.: Fortschritte in der Diagnostik und Therapie der Hypophysenadenome. Zbl. Neurochir. 19, 108–117 (1959).

    CAS  Google Scholar 

  • Marie, P.: Sur deux cas d’acromégalie; hypertrophie singulière, non congénitale, des extrémités supérieures, inférieures et céphaliques. Rev. Méd. (Paris) 6, 297–333 (1886).

    Google Scholar 

  • McGovern, V. J., G. Phillips, and B. D. Wyke: An undifferentiated pituitary adenoma of unusual size. Report of a case. J. Neurosurg. 5, 202–208 (1948).

    Article  PubMed  CAS  Google Scholar 

  • Mogensen, E. F.: Chromophobe adenoma of the pituitary gland. Acta endocr. (Kbh.) 24, 135–152 (1957).

    CAS  Google Scholar 

  • Müller, W.: Ein Beitrag zum Ausbreitungsweg der Hypophysenadenome. Virchows Arch. path. Anat. 293, 253–256 (1934).

    Article  Google Scholar 

  • Müller, W.: Über die Verteilung der Ribonucleinsäure in Hypophysenadenomen. Dtsch. Z. Nervenheilk. 186, 190–196 (1964).

    Google Scholar 

  • Müller, W. u. H. Hoffmann: Über Verkalkungen in Hypophysenadenomen. Zbl. Neurochir. 28, 287–290 (1967).

    Google Scholar 

  • Müller, W. u. H. Hoffmann:, u. F. Oswald: Über das Vorkommen von Cysten in Hypophysentumoren. Zbl. Neurochir. 14, 272–281 (1954).

    Google Scholar 

  • Müller, W. u. H. Hoffmann:, u. F. Oswald:, u. H. W. Pia: Zur Klinik und Ätiologie der Massenblutungen in Hypophysenadenomen. Dfcsch. Z. Nervenheilk. 170, 326–336 (1953).

    Google Scholar 

  • Müller, W. u. H. Hoffmann:, u. F. Oswald:, u. H. W. Pia, u. G. Udvarhelyi: Über Kolloidentartung und Verkalkung von Tumorzellen in Hypophysenadenomen. Endokrinologie 32, 129–136 (1955).

    PubMed  Google Scholar 

  • Müller, W. u. H. Hoffmann:, u. F. Oswald:, u. H. W. Pia, u. G. Udvarhelyi:, u. W. Walter: Zur Frage der Gefäßversorgung in den Adenomen der Hypophyse. Acta neuroveg. (Wien) 8, 446–450 (1954).

    Article  Google Scholar 

  • Olivecrona, H.: Die spezielle Chirurgie der Gehirnkrankheiten. Bd. III, pp. 193–374. Stuttgart: F. Enke 1941.

    Google Scholar 

  • Paillas, J. E., M. Gazaix et D. Pache: Considérations sur une série chirurgicale d’adénomes de l’hypophyse. Rev. Oto-neuro-ophthal. 29, 1–15 (1957).

    CAS  Google Scholar 

  • Pakulat, M. P.: Untersuchungen an Hypophysenadenomen mit Methoden der Eiweißhisto-chemie. Inaug.-Diss. Med. Fak., Köln 1965.

    Google Scholar 

  • Pearse, A. G. E.: Cytochemical localization of the protein hormones of the anterior hypophysis. Ciba Foundation, Coll. on Endocrin. (London) 4, 1–19 (1952).

    Google Scholar 

  • Pearse, A. G. E.: Cytological and cytochemical investigations on the foetal and adult hypophysis in various physiological and pathological states. J. Path. Bact. 65, 355–370 (1953).

    Article  PubMed  CAS  Google Scholar 

  • Pearse, A. G. E.: Cytology and Cytochemistry of adenomas of the human hypophysis. Acta Un. int. Cancr. 18, 302–304 (1962).

    PubMed  CAS  Google Scholar 

  • Pearse, A. G. E.:, and S. van Noorden: The histoenzymology of the human adenohypophysis. Coll. Intern. Centre Nat. Rech. Sci. Paris 1963, pp. 63–72.

    Google Scholar 

  • Pouyanne, L., H. Pouyanne et L. Arne: La forme hémorrhagique de adenomes chromophobes hypophysaires (apropos de trois observations). Hommage à Clovis Vincent, Maloine 1949.

    Google Scholar 

  • Robertson, E. G.: Encephalography. Springfield (Ill.): Ch. C. Thomas, 1957.

    Google Scholar 

  • Roussy, G., et Ch. Oberling: Contribution à l’étude des tumeurs hypophysaires. Presse méd. 41, 1799–1804 (1933).

    Google Scholar 

  • Russfield, A. B., L. Reiner, and H. Klaus: The endocrine significance of hypophyseal tumors in man. Amer. J. Path. 32, 1055–1075 (1956).

    PubMed  Google Scholar 

  • Rutenburg, A. M., S. H. Rutenburg, B. Monis, R. Teague, and A. M. Seligman: Histochemical demonstration of ß-D-galactosidase in the rat. J. Histochem. Cytochem. 6, 122–129 (1958).

    Article  PubMed  CAS  Google Scholar 

  • Sato, I.: The volumetric and cytological studies in the anterior pituitary glands of the castrated human females. J. Iwate med. Ass. 12, 1119–1142 (1961).

    Google Scholar 

  • Schaeffer, J. P.: Some points in the regional anatomy of the optic pathway, with especial references to tumors of the hypophysis cerebri and resulting ocular changes. Anat. Rec. 28, 243–279 (1924).

    Article  Google Scholar 

  • Schönemann, A.: Hypophysis und Thyroidea. Virch. Arch. path. Anat. 129, 310–336 (1892).

    Google Scholar 

  • Tönnis, W.: Diagnostik der intrakraniellen Geschwülste. In: Hdb. Neuroehir. III, Berlin-Göttingen-Heidelberg: Springer 1962.

    Google Scholar 

  • Vosskühler, P.: Ein weiterer Beitrag zur Ausbreitungsweise der Hypophysenadenome. Z. ges. Neurol. Psychiat. 169, 444–451 (1940).

    Article  Google Scholar 

  • Wechsler, W., u. H.-A. Hossmann: Elektronenmikroskopische Untersuchungen chromo-phober Hypophysenadenome des Menschen. Zbl. Neurochir. 26, 105–122 (1965).

    CAS  Google Scholar 

  • Weinberger, L. M., F. H. Adler, and F. C. Grant: Primary pituitary adenoma and the syndrome of the cavernous sinus. A clinical and anatomic study. Arch. Ophthal. 24, 1197–1235 (1940).

    Article  Google Scholar 

  • White, J. C., and S. Warren: Unusual size and extension of a pituitary adenoma. J. Neurosurg. 2, 126–139 (1945).

    Article  Google Scholar 

  • Young, D. G., R. L. Bahn, and R. V. Randall: Pituitary tumors associated with acromegaly. J. clin. Endocr. 25, 249–259 (1965).

    Article  PubMed  CAS  Google Scholar 

  • Younghusband, O. Z., G. Horrax, L. M. Hurxthal, H. F. Hare, and J. L. Poppen: Chromophobe pituitary tumors. J. clin. Endocr. 12, 611–630 (1952).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Pathologisches Institut, Universität Köln, Deutschland

    W. Müller

Authors
  1. W. Müller
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Pathologisches Institut der Universität, 6300, Gießen, Klinikstraße 32g, Deutschland

    Joachim Kracht

Rights and permissions

Reprints and permissions

Copyright information

© 1969 Springer-Verlag Berlin · Heidelberg

About this chapter

Cite this chapter

Müller, W. (1969). Pathologie der Hypophysentumoren. In: Kracht, J. (eds) Oestrogene Hypophysentumoren. Oestrogene Hypophysentumoren, vol 15. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-95126-8_42

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-95126-8_42

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-95127-5

  • Online ISBN: 978-3-642-95126-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation