Bradykininogen in the Blood of Women during Pregnancy, Labor, and Puerperium

  • P. Periti
  • F. Gasparri


The unexplained increase of oxytocic but thioglycolate-resistant activity in the blood during labor (Centaro et al., 1959, 1961; Hawker et al., 1961; Armstrong and Stewart, 1960) induced us (Periti et al., 1962) and also others (Martinez et al., 1962) to study the behavior of bradykininogen in plasma in this clinical condition. As this increase in oxytocic activity is due to polypeptides such as plasma kinin and slow-reacting substances in general, the behavior of the inactive blood precursor of some of these substances (i.e. bradykininogen) assumes particular significance. First it was thought that plasma kinin activated during labor would act synergistically with oxytocin on the uterus, which is the common target organ. Bradykinin and kinin derived from the plasma of a woman in labor, however, have no oxytocic effect on the human uterus in vitro (Berde and Saameli, 1961; Centaro et al., 1963), the oxytocic activity obtained in vivo with high doses of bradykinin or by means of pharmacological endogenous activation of the plasma kinin is certainly not to be attributed to a direct action on the uterus of these polypeptides (Berde and Saameli, 1961; Centaro and Massi, 1962).


Uterine Contraction Post PARTUM Reactive Hyperemia Human Uterus Parturient Woman 
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Copyright information

© Springer-Verlag New York Inc. 1966

Authors and Affiliations

  • P. Periti
    • 1
  • F. Gasparri
    • 1
  1. 1.Istituto di Farmacologia e Istituto di Clinica OstetricaUniversita degli Studi di FirenzeFlorenceItaly

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