Skip to main content
SpringerLink
Log in

Pathogenese der Poliomyelitis

  • Conference paper
Klinische Probleme der Poliomyelitis und verwandter Viruskrankheiten

Part of the book series: Freiburger Symposion an der Medizinischen Universitäts-Klinik ((FREIBURGER,volume 8))

Zusammenfassung

Als erster fester Ansatzpunkt für das experimentelle Studium der Pathogenese der Poliomyelitis gilt der Versuch von Landsteiner und Popper aus dem Jahre 1909 (24). Die Autoren verimpften eine bakterienfreie Emulsion des Rückenmarks eines an Poliomyelitis gestorbenen Menschen intraperitoneal an Rhesusaffen. 7–14 Tage später erkrankten die Tiere u. a. mit schlaffen Lähmungen. Das der menschlichen Poliomyelitis ähnliche Krankheitsbild war mit Hilfe der gleichen Technik von einem zum anderen Affen übertragbar. Der Erreger wurde der Klasse der Viren zugeordnet. Heute, 50 Jahre später, läßt sich das klassische Problem jeder Infektionskrankheit, der Eintritt, die Ausbreitung und die Wirkung des Erregers im Organismus für die durch das Poliovirus hervorgerufene Erkrankung in einige Teilfragen gliedern.

  1. 1.

    Worin besteht der pathogenetische Elementarvorgang der Infektion ?

  2. 2.

    Welche Gewebe des Organismus werden primär infiziert ?

  3. 3.

    Welchen Weg nimmt das Virus von den primär infizierten Geweben in das ZNS?

  4. 4.

    Worin liegt die Ursache für die Erkrankung des ZNS, welche Rolle spielen Eigenschaften des Erregers, welche Rolle spielen Abwehrmechanismen des Organismus ?

Aus dem Hygiene-Institut der Universität Freiburg i. B. (Direktor: Prof. Dr. R. Haas)

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 44.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 59.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

Literatur

  1. Alexander, H. E., G. Koch, I. M. Mountain, K. Sprunt and O. Van Damme: Infectivity of ribonucleic acid of poliovirus on Hela Cell monolayers. Virology 5, 172 (1958).

    Article  PubMed  CAS  Google Scholar 

  2. Ackermann, W. W.: Cellulär aspects of the cell-virus relationship. Bact. Rev. 23, 223 (1959).

    Google Scholar 

  3. Bodian, D.: A reconsideration of the pathogenesis of poliomyelitis. Amer. J. Hyg. 55, 414 (1952).

    PubMed  CAS  Google Scholar 

  4. Bodian, D.: Emerging concept of poliomyelitis infection. Science 122, 105 (1955).

    Article  PubMed  CAS  Google Scholar 

  5. Bodian, D.: Poliomyelitis: Pathogenesis and histopathology. In: Rivers/Horsfall Jr. “Viral and rickettsial infections of man”. Philadelphia: 3 nd edition. J. B. Lippincott Co.

    Google Scholar 

  6. Bodian, D.: Viremia, invasiveness and the influence of injections. Ann. N. Y. Acad. Sci. 61, 877 (1955).

    Article  PubMed  CAS  Google Scholar 

  7. Colter, J. S., H. H. Bird, A. W. Moyer and R. A. Brown: Infectivity of ribonucleic acid isolated from virus infected tissues. Virology 4, 522 (1957).

    Article  PubMed  CAS  Google Scholar 

  8. Dinnebacke, T. H.: The yield of poliovirus from individual cells in tissue culture. Virology 7, 243 (1959).

    Article  Google Scholar 

  9. Enders, F., T. H. Weller and F. C. Robbins: Cultivation of the Lansing strain of poliomyelitis virus in cultures of various human embryonic tissues. Science 109, 85 (1949).

    Article  PubMed  CAS  Google Scholar 

  10. Fogh, J., and D. C. Stuart Jr.: Intracellular crystalls of polioviruses in HeLa cells. Virology 11, 308 (1960).

    Article  PubMed  CAS  Google Scholar 

  11. Gelfand, H. M., L. Potash, D. R. Le Blanc and J. P. Fox: Revised preliminary report on the Louisiana observations of the natural spread within families of living vaccine strains of poliovirus. In: Live poliovirus vaccines. First Intern. Conf. Scient. Pub. No. 44 of the Pan Americain Health Organization pp. 203 (1959).

    Google Scholar 

  12. Goon, R. A., R. A. Bridges and R. M. Condie: Host-parasite relationsships in patients with dysproteinemias. Bact. Rev. 24, 115 (1960).

    Google Scholar 

  13. Gierer, A., u. G. Schramm: Die Infektiosität der Nucleinsäure aus Tabakmosaikvirus. Z. Naturforsch. lib, 138 (1956).

    Google Scholar 

  14. Holland, J. J., L. C. Mclaren and J. T. Syverton: The mammalian cell virus relationship IV. Infection of naturally insusceptible cells with enterovirus ribonucleic acid. J. exp. Med. 110, 65 (1959).

    Article  PubMed  CAS  Google Scholar 

  15. Howes, D. W.: The growth cycle of poliovirus in cultures cells. III. The asynchronous response of HeLa cells multiply infected with type 1 poliovirus. Virology 9, 110 (1959).

    Article  PubMed  CAS  Google Scholar 

  16. Horstmann, D. M.: Poliomyelitis virus in blood of orally infected monkeys and chimpanzees. Proc. Soc. exp. Biol. N. Y. 79, 417 (1952).

    CAS  Google Scholar 

  17. Horstmann, D. M.: Poliomyelitis: Problems in pathogenesis and immunization. The Yale J. Biol. Med. 30, 81 (1957).

    CAS  Google Scholar 

  18. Horstmann, D. M.: Acute poliomyelitis: relation of physical activity at the time of onset to the course of the disease. J. Amer. med. Ass. 142, 236 (1950).

    Article  CAS  Google Scholar 

  19. Ho, M., and J. F. Enders: An inhibitor of viral activity in infected cell cultures. Proc. Nat. Acad. Sci. (Wash.) 45, 385 (1959).

    Article  CAS  Google Scholar 

  20. Holt, L. B.: A reassessment of the risk of provoking paralytic poliomyelitis by making prophylactic inoculation against diphtheria and pertussis. J. Hyg. (Lond.) 57, 150 (1959).

    Article  CAS  Google Scholar 

  21. Hsiung, G. D., and J. L. Melnick: Effect of sodium bicarbonate concentration in plaque formation of virulent and attenuated polioviruses. J. Immunol. 80, 282 (1958).

    PubMed  CAS  Google Scholar 

  22. Herndon, C. N., and R. G. Jennings: A twin family study of susceptibility to poliomyelitis. Amer. J. hum. Genet. 3, 17 (1951).

    PubMed  CAS  Google Scholar 

  23. Isaacs, A., and J. Lindenmann: Virus interference I. I.terferon. Proc. roy. Soc. B. 147, 258 (1957).

    Article  CAS  Google Scholar 

  24. Landsteiner, K., u. F. Popper: Übertragung der Poliomyelitis acuta auf Affen. Z. Immun -Forsch. 2, 377 (1909).

    Google Scholar 

  25. Lwoff, A. R., R. Dulbecco and M. Vogt: Kinetics of release of poliomyelitis virus from single cells. Virology 1, 128 (1955).

    Article  PubMed  CAS  Google Scholar 

  26. Lwoff, A.: Factors influencing the evolution of viral diseases at the cellular level and in the organism. Bact. Rev. 23, 109 (1959).

    PubMed  CAS  Google Scholar 

  27. Lwoff, A., M. Lwoff: Remarques sur quelques caractères du dévelopement du virus de la poliomyélite. C. R. Soc. Biol. 248, 1725 (1959).

    CAS  Google Scholar 

  28. Melnick, J. L., and J. C. Brennan: Monkey neurovirulence of attenuated polioviruses vaccines being used in field trials. In: Live poliovirus vaccines. First Intern. Conf., Scient. Pub. No. 44 of the Pan Americain Health organization. p. 101 (1959).

    Google Scholar 

  29. Melnick, J. L., and N. Ledinko: Vaccination as a provoking factor in poliomyelitis: an experimental approach. J. infect. Dis. 90, 279 (1952).

    Article  Google Scholar 

  30. Paffenbarger, R. S., and V. O. Wilson: Previous tonsillectomy and current pregnancy as they affect risk of poliomyelitis attack. Ann. N. Y. Acad. Sci. 61, 856 (1955).

    Article  PubMed  Google Scholar 

  31. Russel, W. R.: Paralytic poliomyelitis. The early symptoms and the effect of physical activity on the course of the disease. Brit. Med. J. 1, 465 (1949).

    Article  Google Scholar 

  32. Sabin, A. B., and R. Ward: The natural history of poliomyelitis; distribution of virus in nervous and non-nervous tissues. J. exp. Med. 73, 771 (1941).

    Article  PubMed  CAS  Google Scholar 

  33. Sabin, A. B., and R. Ward: Pathogenesis of poliomyelitis. Reappraisal in the light of new data. Science 123, 1151 (1956).

    Article  PubMed  CAS  Google Scholar 

  34. Shwartzman, G., ST. M. Aronson, C. Teodorii, M. Adler and R. Jahiel Endocrinological aspects of pathogenesis of experimental poliomyelitis. Ann. N. Y. Acad. Sci. 61, 869 (1955).

    Article  PubMed  CAS  Google Scholar 

  35. Syverton, J. T., K. T. Brunner, J. O. H. Tobin and M. M. Cohen: Recovery of viable virus from poliomyelitis vaccine by use of monkeys pretreated with cortisone and x-radiation. Amer. J. Hyg. 64, 74 (1956).

    PubMed  CAS  Google Scholar 

  36. Haas, R., R. Thomssen u. G. Reimold: Über die Infektiosität von Phenolextrakten aus Coxs. A infizierten saugenden Mäusen. (In Vorbereitung).

    Google Scholar 

  37. Trask, J. D., A. J. Vignec and J. R. Paul: Poliomyelitis virus in human stools. J. Amer. med. Ass. 111, 6 (1938).

    Article  Google Scholar 

  38. M., R. Dulbecco and H. A. Wenner: Mutants of poliomyelitis viruses with reduced efficiency of platings in acid medium and reduced neuropathogenicity. Virology 4, 141 (1957).

    Article  PubMed  Google Scholar 

  39. Wagner, R. R.: Viral interference. Bact. Rev. 24, 151 (1960).

    PubMed  CAS  Google Scholar 

  40. Weinstein, L.: Influence of age and sex on susceptibility and clinical manifestations in poliomyelitis. New. Engl. J. Med. 257, 47 (1957).

    Article  PubMed  CAS  Google Scholar 

  41. Weinstein, L.: Brit. Med. Research Council Committee: Poliomyelitis and prophylactic inoculation against diphtheria, whooping cough and smallpox. Lancet 1956II, 1223.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Freiburg i. Br., Deutschland

    R. Thomssen

Authors
  1. R. Thomssen
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Medizinische Universitäts-Klinik, Freiburg i. Br., Deutschland

    F. Wöhler

  2. Universitäts-Kinderklinik, Freiburg i. Br., Deutschland

    O. Vivell

Rights and permissions

Reprints and permissions

Copyright information

© 1961 Springer-Verlag OHG. Berlin · Göttingen · Heidelberg

About this paper

Cite this paper

Thomssen, R. (1961). Pathogenese der Poliomyelitis. In: Wöhler, F., Vivell, O. (eds) Klinische Probleme der Poliomyelitis und verwandter Viruskrankheiten. Freiburger Symposion an der Medizinischen Universitäts-Klinik, vol 8. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-94813-8_3

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-94813-8_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-02662-4

  • Online ISBN: 978-3-642-94813-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation