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Das Renin-Angiotensin-System: Physiologie und Pathophysiologie

  • S. Gallinat
  • O. Edling
  • Thomas Unger
Conference paper

Zusammenfassung

Das Renin-Angiotensin-System (RAS) mit seinem Effektorpeptid Angiotensin II (Ang II) als zirkulierendem Hormon wird seit langem als ein klassisches endokrines System angesehen. Die Entdeckung des Renins geht auf das Jahr 1898 zurück, als Tigerstedt und Bergmann die Beobachtung machten, daß durch Injektion eines Kaninchennierenextrakts eine Blutdrucksteigerung bei Kaninchen erzielt werden kann [283]. In den folgenden Jahrzehnten wurde die Existenz des Vasopressors Renin kontrovers diskutiert, und erst 1934 wurde die Bedeutung von Renin für die Blutdruckregulation von Goldblatt erneut erkannt [101]. Seiner Forschungsgruppe gelang es, einen Zusammenhang zwischen Renin-Freisetzung und renaler Ischämie nachzuweisen. Nur wenige Jahre später, 1937, diskutierten Blalock und Levy die Abhängigkeit der Renin-Freisetzung vom renalen Perfusionsdruck [20] und kamen zu dem Schluß, daß renale Barorezeptoren dabei eine Rolle spielen mußten [285]. Die physiologische und biochemische Charakterisierung von Renin wurde in den folgenden Jahren vervollständigt.

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Copyright information

© Dr. Dietrich Steinkopff Verlag GmbH & Co. KG, Darmstadt 1999

Authors and Affiliations

  • S. Gallinat
  • O. Edling
  • Thomas Unger
    • 1
  1. 1.Institut für PharmakologieKlinikum der Christian-Albrechts-Univ. KielKielDeutschland

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