Abstract
Both pronethalol *) and propranolol **) have been found to abolish adrenaline-induced arrhythmias, and ouabain-induced arrhythmias. This has led to speculation as to how these two compounds act against arrhythmias, whether they act by virtue of their beta-blocking capacity or some other property. Howe and Shanks (1) have shown that arrhythmias caused by injection of adrenaline, 2 μg/kg, into cats breathing halothane 1%> in oxygen were abolished after as low a dose as 0.1 mg/kg propranolol. Up to 10 μg/kg adrenaline were then necessary to evoke further ectopics. This antiarrhythmic action would appear to depend on antagonism of beta-adrenergic receptors.
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© 1967 Dietrich Steinkopff Verlag, Darmstadt
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Rouse, W. (1967). The Effects of Propranolol and Ouabain on the Conducting System of the Hearts in Dogs. In: Haan, D. (eds) Beta-Rezeptoren-Blockade. Kreislauf-Bücherei, vol 23. Steinkopff. https://doi.org/10.1007/978-3-642-93659-3_12
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DOI: https://doi.org/10.1007/978-3-642-93659-3_12
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