Abstract
Gram-negative septicaemia is a frequent complication following major surgery in high-risk patients and is a serious condition. Its mortality ranges from 40% to 60%, a rate which has remained unchanged in the past few decades, despite advances in general intensive medical care, modern antibiotic treatment, and new intervention modalities for the treatment of diffuse intravascular coagulation (DIC). This may be partly due to the increasing age of the general population and the increasing number of major surgical interventions in the elderly.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Van Deventer SJH, Büller HR, ten Cate JW, et al. (1990) Experimental endotoxaemia in humans: analysis of cytokine release and coagulation, fibrinolytic, and complement pathways. Blood 76: 2520–2526
Suffredini AF, Harpel PC, Parillo JE (1989) Promotion and subsequent inhibition of plasminogen activator after administration of intravenous endotoxin to normal subjects. N Engl J Med 18: 1165–1171
Taylor Jr FB, Esmon CT, Hinshaw LB (1991) Summary of staging mechanism and intervention studies in the baboon model of E. Coli sepsis. J Traumatol [Suppl] 12: 197–204
Taylor Jr FB, Chang A, Esmon CT, et al. (1988) Antithrombin-III prevents the lethal effects of Escherichia Coli infusions in baboons. Circ Shock 26: 227–235
Taylor Jr FB, Chang A, Esmon CT, et al. (1987) Protein C prevents the coagulopathic and lethal effects of Escherichia Coli infusion in the baboon. J Clin Invest 79: 918–925
Levi M, Hack CE,, de Boer JP et al. (1991) Reduction of contact activation related fibrinolytic activity in factor XII deficient patients. J Clin Invest 88: 1155–1160
Van der Poll T, Büller HR, ten Cate H, et al. (1990) Activation of coagulation after administration of tumor necrosis factor to normal subjects. N Engl J Med 322: 1622–1626
Bauer KA, ten Cate H, Spriggs DR, et al. (1989) Tumor necrosis factor infusions have a procoagulant effect on hemostatic mechanism of humans. Blood 74: 165–172
Blauhut B, Kramer H, Vinazzer H, Bergmann H (1985) Substitution of antithrom- bin-III in shock and DIC: a randomized study. Thromb Res 39: 81–89
Fourrier F, Chopin C, Huart JJ, Range I, Caron C, Goudemand J (1992) Double-blind, placebo-controlled trial of antithrombin-III concentrates in septic shock with disseminated intravascular coagulation [abstract]. Intensive Care Med 18: S50
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1994 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
ten Cate, J.W., van Beek, E.J.R. (1994). Sepsis and Disseminated Intravascular Coagulation: Pathophysiological and Interventional Concepts. In: Martin, E., Nawroth, P.P. (eds) Fachübergreifende Aspekte der Hämostaseologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-93561-9_2
Download citation
DOI: https://doi.org/10.1007/978-3-642-93561-9_2
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-58054-6
Online ISBN: 978-3-642-93561-9
eBook Packages: Springer Book Archive