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Gentherapie als mögliche Behandlungsstrategie für kardiovaskuläre Erkrankungen

  • Chapter
Interventionen am Herzen

Zusammenfassung

Die Anwendung molekularbiologischer Techniken in der kardiovaskulären Forschung hat sich derartig schnell ausgebreitet, daß traditionelle Konzepte der Physiologie und Pharmakologie kardiovaskulärer Organe durch neue Konzepte der zellulären und molekularen Regulation revolutioniert worden sind [35]. Im Hinblick auf das kardiovaskuläre System sind wir Zeuge eines fundamentalen Paradigmenwechsels geworden. Wurden noch vor 50 Jahren Herz und Blutgefäße als mechanische Organe angesehen, die auf Nervensignale und Hormone reagieren, so gelten sie heute als biologisch aktive Organe. Diese können Substanzen synthetisieren die wiederum an der Regulation kardialer und vaskulärer Funktionen beteiligt sind [19, 20]. Es ist in den letzten Jahren deutlich geworden, daß die komplexen Organe des kardiovaskulären Systems zu einer sensiblen Wahrnehmung bestimmter Einflußgrößen fähig sind.

There is no doubt that the development and application of recombinant DNA technology has put us at the threshold of new forms of medicine.

Paul Berg [6]

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Authors
  1. H. E. von der Leyen
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  2. V. J. Dzau
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Editors and Affiliations

  1. Herzchirurgie Salzburg, Müllner Hauptstraße 48, A-5020, Salzburg, Österreich

    Felix Unger

  2. Medizinische Klinik, Diakonissenkrankenhaus Mannheim, Akademisches Lehrkrankenhaus der Universität Heidelberg, Speyerer Straße 91-93, D-68163, Mannheim, Deutschland

    Hubert Mörl

  3. Fachpharmakologe DGPT, Am Huhlchen 5, D-55130, Mainz, Deutschland

    Hans Armin Dieterich

  4. School of Medicine, Dpts. of Medicine and Pharmacology, Georgetown University, Washington D.C., USA

    Hans Armin Dieterich

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von der Leyen, H.E., Dzau, V.J. (1995). Gentherapie als mögliche Behandlungsstrategie für kardiovaskuläre Erkrankungen. In: Unger, F., Mörl, H., Dieterich, H.A. (eds) Interventionen am Herzen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-93558-9_41

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