Advertisement

Informatics in Molecular Biology

  • Howard Bilofsky
Part of the Lecture Notes in Medical Informatics book series (LNMED, volume 45)

Abstract

There is growing recognition that advances in basic biological research and biotechnology are increasingly dependent upon the effective management of information using computer technology. The rapid changes in many aspects of both the science and the technology have led to a serious problem of providing for the bioinformatics needs of European scientists. This is nowhere more evident than in molecular biology where efforts to understand the relationship of biological function and macromolecular structure have generated relatively large databases and often require a multidisciplinary approach and the need for information from new and diverse sources. Recent initiatives to map and sequence a number of genomes will lead to considerable new biological understanding, but will only exacerbate these problems.

Meeting this challenge will require new approaches to organising and funding bioinformatics resources in Europe. Long-term infrastructural support is required to ensure that stable multidisciplinary expertise is focused on bioinformatics and is widely available. The European Molecular Biology Laboratory (EMBL) is home to the EMBL Data Library, a key component of the international sequence database community, which is on the front-line facing these challenges. A European Bioinformatics Institute (EBI) is planned which will address the expected growth in our own database management and distribution activities, provide consulting and training, encourage the development of new designs, tools and interfaces for relevant databases and computational resources, enhance the professional and cooperative nature of the bioinformatics community and represent European interests as a leader in the international arena.

Keywords

molecular biology bioinformatics European infrastructure 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. [1]
    Gilbert, W., Towards a paradigm shift in biology. Nature, 349: 99; 1991.CrossRefGoogle Scholar
  2. [2]
    Bioinformatics in Europe 2. Strategy for a European biotechnology information infrastructure. European Chemical Industry Federation; 1990.Google Scholar
  3. [3]
    FAST - Research Activities, CEC, EUR-7102; 1980.Google Scholar
  4. [4]
    Cantley, M.F., Bio-informatics in Europe, Foundations and Visions. Swiss Biotech, 4: 7–14; 1984.Google Scholar
  5. [5]
    Berendsen, H J.C., A Bio-Informatics Workstation, Report for the European Economic Community under the “IT for BT” Initiative; June, 1986.Google Scholar
  6. [6]
    Doolittle, R.F., ed., “Molecular Evolution: Computer Analysis of Protein and Nucleic Acid Sequences” Methods Enzymol., 183; 1990.Google Scholar
  7. [7]
    Kahn, P. and Cameron, G., EMBL Data Library, Methods Enzymol., 183: 23–31; 1990.CrossRefGoogle Scholar
  8. [8]
    Stoehr, P.J., and Cameron, G., The EMBL Data Library, Nucl. Acids Res. (in press); 1991.Google Scholar
  9. [9]
    Bilofsky, H., Advanced technology for sequence data banks. “Biotechnology Information ’86”, R. Wakeford ed., IRL Press, 31–34; 1987.Google Scholar
  10. [10]
    Report on Genome Research 1991. The European Science Foundation; 1991.Google Scholar
  11. [11]
    Research on the Human Genome in Europe and its Relationship to Activities Elsewhere in the World. Academia Europaea; 1991.Google Scholar
  12. [12]
    Pearson, M.L., and Söll, D., The Human Genome Project: a paradigm for information management in the life sciences, FASEB J., 5: 35–39; 1991.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • Howard Bilofsky
    • 1
  1. 1.European Molecular Biology LaboratoryHeidelbergGermany

Personalised recommendations