Der Abbau der Purinnukleotide betrifft sowohl die Polynukleotide DNS und RNS als auch die auf Adenin und Guanosin basierenden Mononukleotide. DNS hat die niedrigste Umsatzrate, Mononukleotide die höchste (Abb. 2.14).


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Duley JA, Simmonds HA, Hopkinson DA, Levinsky RJ (1990) Further evidence of a ‚new ‘purine defect, inosine triphosphate (ITP) pyrophosphohydrolase deficiency in a kindred with adenosine deaminase deficiency’. Clin Chim Acta (in press).Google Scholar
  2. Eddy LJ, Stewart JR, Jones HP, Engerson TD, McCord JE, Downey JM (1987) Free radical-producing enzyme, xanthine oxidase, is undetectable in human hearts. Am J Physiol 253: H709–H711.PubMedGoogle Scholar
  3. Gerlach E, Becker BF (eds) (1987) Topics and perspectives in adenosine research. Springer, Berlin Heidelberg New York Tokyo.Google Scholar
  4. Hershfield MS (1983) S-adenosylhomocysteine hydrolase as a target in genetic and drug-induced deficiency of adenosine deaminase. In: Berne RM, Rall TW, Rubio R (eds) Regulatory function of adenosine. Martinus Nijhoff, The Hague, pp 171–179.CrossRefGoogle Scholar
  5. Hitchings GH (1978) Uric acid: chemistry and synthesis. In: Kelley WN, Weiner IM (eds) Uric acid. Springer, Berlin Heidelberg New York, pp 1–20.CrossRefGoogle Scholar
  6. Marcolongo R, Marinello E, Pompucci G, Pagani R (1974) The role of xanthine oxidase in hyperuricaemic states. Arthritis Rheum 17: 430–438.PubMedCrossRefGoogle Scholar
  7. Simmonds HA (1987) Purine and pyrimidine disorders. In: Holton JB (ed) The inherited metabolic diseases. Churchill Livingstone, Edinburgh, pp 215–225.Google Scholar
  8. Simmonds HA, Rising TJ, Cadenhead A, Hatfield PJ, Jones AS, Cameron JS (1973) Radioisotope studies of purine metabolism during the administration of guanine and allopurinol in the pig. Biochem Pharmacol 22: 2553–2563.CrossRefGoogle Scholar
  9. Simmonds HA, Sahota AS, Van Acker KJ (1988 a) Adenine phosphoribosyltransferase deficiency and 2,8-dihydroxyadenine lithiasis. In: Scriver CR, Beaudet AL, Sly WS, Valle D (eds) The metabolic basis of inherited disease, 6th ed. McGraw-Hill, New York.Google Scholar
  10. Thompson LF (1986) Ecto-5′-nucleotidase can use IMP to provide the total purine requirements of mitogen-stimulated human T cells and human B lymphoblasts. Adv Exp Med Biol 195B: 467–473.Google Scholar
  11. Willis RC, Kaufman AH, Seegmiller JE (1984) Purine nucleotide reutilisation by human lymphoblast lines with abberrations of the inosinate cycle. J Biol Chem 259: 4157–4161.PubMedGoogle Scholar
  12. Wyngaarden JB, Kelley WN (1983) Gout. In: Stanbury JB, Wyngaarden JB, Fredrickson DS, Goldstein JL, Brown MS (eds) The metabolic basis of inherited disease, 5th edn. McGraw-Hill, New York, pp 1043–1115.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • H. A. Simmonds

There are no affiliations available

Personalised recommendations