Investigation of Rapid Metabolic Reactions in Whole Organs by Multiple Pulse Labelling
Flux rates of metabolic and transport processes in whole organs may be determined by conventional compartmental system analysis (1,2). However, this approach is not consistent with the events in real organs characterized by continuous variation of tracer concentrations with space. When the events under study are comparable in rate with transit times or recirculation, their adequate description is only possible by using distributed model systems.
KeywordsTransit Time Impulse Response Intracellular Metabolite Tritiated Water Compartmental System
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