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Systems Theory in Immunology pp 165–174Cite as

Systems Compartmentation in Immunological Modeling

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Part of the book series: Lecture Notes in Biomathematics ((LNBM,volume 32))

Abstract

A nonlinear model of the humoral immune system is studied with blood, bone marrow, spleen, and gut-associated lymph tissue, lymph and lymph nodes represented by four compartments. Bilinear structures appear as the basis of the open-loop processes which include cell division and differentiation followed by chemical binding of molecular antibodies and antigen. A preliminary analysis is made of system identifiability in terms of compartmental accessibility for tracer insertion and tracer measurement.

Research supported by US National Science Foundation Grant No. ENG 74–15503A01.

Formerly at Oregon State University.

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References

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Author information

Authors and Affiliations

  1. Department of Computing and Control, Imperial College of Science & Technology, 180 Queen’s Gate, London, SW7 3BZ, UK

    R. R. Mohler

  2. Department of Electrical Engineering, Washington State University, Pullman, WA, USA

    C. S. Hsu

  3. Department of Electrical and Computer Engineering, Oregon State University, Corvallis, OR, 97331, USA

    R. R. Mohler

Authors
  1. R. R. Mohler
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  2. C. S. Hsu
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Editor information

Editors and Affiliations

  1. Istituto di Automatica, University of Rome, Via Eudossiana 18, 00184, Rome, Italy

    Carlo Bruni

  2. Chen-Euratom Immunogenetics Group, Laboratory of Radiopathology, C.S.N. Casaccia, Rome, Italy

    Gino Doria

  3. Istituto Matematico “G. Castelnuovo”, University of Rome, Rome, Italy

    Giorgio Koch

  4. Istituto di Chimica-Biologica, Facolta di Medicina e Chirurgia, University of Rome, 00185, Rome, Italy

    Roberto Strom

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© 1979 Springer-Verlag Berlin Heidelberg

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Mohler, R.R., Hsu, C.S. (1979). Systems Compartmentation in Immunological Modeling. In: Bruni, C., Doria, G., Koch, G., Strom, R. (eds) Systems Theory in Immunology. Lecture Notes in Biomathematics, vol 32. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-93130-7_14

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  • DOI: https://doi.org/10.1007/978-3-642-93130-7_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-09728-0

  • Online ISBN: 978-3-642-93130-7

  • eBook Packages: Springer Book Archive

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