Abstract
Variations of antibody affinity with antigen dose and time after immunization, such as a more rapid increase of affinity after lower doses of antigen (1), have been explained by the maturation theory (2). According to this theory, there are specific B lymphocytes with different receptor affinity prior to antigenic stimulation. Upon interaction of cell receptors with antigen the lymphocyte will proliferate and secrete antibodies with the same affinity as that of the cell receptors. As the antigen concentration decreases with time after immunization, the higher affinity cells will be selected out and predominate in the population. After lower doses of antigen this selection proceeds more rapidly than after higher doses. Hence, during the immune response there are parallel changes in average affinity at the serum antibody and cell receptor level (3, 4).
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© 1979 Springer-Verlag Berlin Heidelberg
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Doria, G. (1979). Biological Variations of IgM Antibody Affinity. In: Bruni, C., Doria, G., Koch, G., Strom, R. (eds) Systems Theory in Immunology. Lecture Notes in Biomathematics, vol 32. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-93130-7_10
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DOI: https://doi.org/10.1007/978-3-642-93130-7_10
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