Abstract
The clinician usually uses laboratory data in a univariate mode, i.e. he evaluates each value with respect to health or disease. There is, however, much information contained in a simultaneously measured group of laboratory test results, which is not fully exploited by this way of evaluation. Multivariate analysis is required in order to take full advantage of the data obtained (1–7).
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Johnson, E.A., Some applications of profile analysis and clustering techniques based on clinical chemistrv data. Scand. J. Clin. Lab. Invest. 29, Suppl. 126, 20. 3 (1972).
Grams, R.R., Johnson, E.A., and Benson, E.S., Laboratory data analysis system: Section III - Multivariate normality. Am. J. Clin. Pathol. 58: 188 (1972).
Grams, R.R., Implication of mass automated instruments on medical practice. Ann. Rev. Med. 27: 199 (1976).
Winkel, P., Patterns and clusters - multivariate approach for inter preting clinical chemistry results. Clin. Chem. 19: 1329 (1973).
Solberg, H.E., Skrede, S., Elgjo, E., Blomhoff, J.P., and Gjone, E. Classification of liver diseases by clinical chemical results and cluster analysis. Scand. J. Clin. Lab. Invest. 36: 81 (1976).
Solberg, H.E., Discriminant analvsis. Crit. Rev. Clin. Lab. Sci. 9: 209 (1978).
Goldberg, D.M., and Ellis, G., Mathematical and computer-assisted procedures in the diagnosis of liver and biliary tract disorders. In: Advances in Clinical Chemistry, Eds. Bodansky, 0., and Latner, A.L. 20:49 (1978).
Kagedal, B., Sandstrom, A., and Tibbling* G., Determination of a trivariate reference region for free thyroxine index, free triiodothyronine index, and thyrotropin from results obtained in a health survey of middle-aged women. Clin. Chem. 24: 1744 (1978).
Kagedal, B., Norr, A., Sorbo, B., and Tegler, L., Thyroid function classification by multivariate analysis of abnormal hormone results obtained in a health survey of middle-aged women. To be published.
Sneath, P.H.A., The application of computers to taxonomy. J. Gen. Microbiol. 17: 201 (1957).
Wishart, D., CLUSTAN user manual, 3rd edition, Program Library Unit Edinburgh University, 1978.
Ward, J.H., Hierarchical grouping to optimize an objective function J. Am. Statist. Ass. 58: 236 (1963).
Wishart, D., Mode analysis. In: Numerical Taxonomy. A.J. Cole, ed., Academic Press, New York, 1969, p 282.
Wishart, D., An improved multivariate mode-seeking cluster method. Proc. R.S.S. ConfHull, England (1973).
Alstrom, T., Grasbeck, R., Hjelm, M., and Skandsen, S., Recommendation concerning the collection of reference values in clinical chemistry and activity report. Scand. J. Clin. Lab. Invest. 35:Suppl. 144, 1 (1975).
Wishart, D., Numerical classification method for deriving natural classes. Nature 221: 97 (1969).
Winkel, P., Lyngbye, J., and Jorgensen, K., The normal region -a multivariate problem. Scand. J. Clin. Lab. Invest. 30: 339 (1972).
Sandel, P., and Vogt, W., A comparison of discriminant methods. In: Computing in clinical laboratories. Ed. Siemaszko, F., Pitman Medical, London 1978.
Grams, R.R., Johnson, E.A., and Benson, E.S., Laboratory data ana-lysis system: Section IV - Multivariate diaanosis. Am. J. Clin. Pathol. 58: 201 (1972).
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Cederblad, G., Kågedal, B., Norr, A., Sörbo, B., Tegler, L., Wigertz, O. (1979). Computer-Assisted Evaluation by Multivariate Reference Region and Cluster Analysis as Applied to Serum Thyroid Hormones and Thyrotropin. In: Barber, B., Grémy, F., Überla, K., Wagner, G. (eds) Medical Informatics Berlin 1979. Lecture Notes in Medical Informatics, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-93120-8_72
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DOI: https://doi.org/10.1007/978-3-642-93120-8_72
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