Abstract
Histochemical analysis of muscle biopsies from patients with myotonic disorders both confirms abnormalities that are observed by ordinary histologic techniques (such as sarcoplasmic masses) and demonstrates new changes detectable only with histochemistry (such as preferential atrophy of type I fibers). The major hereditary disorders with associated myotonia are: (1) myotonia congenita, (2) myotonia dystrophica, and (3) paramyotoniaadynamia. All three are inherited in a dominant pattern. Other examples of myotonia are: (1) hypokalemic periodic paralysis; (2) “myotonia acquisita” — drug induced, with another disease, or idiopathic; and (3) electromyographic myotonia associated with denervation atrophy or inflammatory myopathies.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Engel, W. K., D. E. McFarlin, G. A. Drews, and R. D. Wochner: Protein abnormalities in neuromuscular diseases, Parts 1 & 2. J. Amer. med. Ass. 195, 754, 837 (1966).
Eulenburg, A.:I. Originalmitteilungen. Über eine familiäre, durch sechs Generationen verfolgbare Form congenitaler Paramyotonie. Zbl. ges. Neurol. Psychiat. 5, 265 (1886).
Gamstrop, I.:Adynamia episodica hereditaria and myotonia. Acta psychiat. scand. 39, 41 (1963).
Drager, G. A., J. F. Hammill, and G. M. Shy: Paramyotonia congenita. Arch. Neurol. Psychiat. (Chic.) 80, 1 (1958).
Resnick, J. S., and W. K. Engel: Unpublished observations 1966.
Engel, W. K.:A clinical approach to the myopathies. A symposium Review of Current Concepts of Myopathies. In Clinical Orthopaedics and Related Research. A. F. De Palma, Ed., Vol. 39, p. 6. Philadelphia: J. B. Lippincott 1965.
Engel, W. K.:The essentiality of histo- and cytochemical studies of skeletal muscle in the investigation of neuromuscular disease. Neurology (Minneap.) 12, 778 (1962).
Engel, W. K.:Diseases of the neuromuscular junction and muscle. In Neurohistochemistry. C. Adams, Ed., p. 622. Amsterdam: Elsevier Press 1965.
Engel, W. K.:Muscle biopsy. A symposium Review of Current Concepts of Myopathies. In Clinical Orthopaedics and Related Research. A. F. De Palma, Ed., Vol. 39, p. 80. Philadelphia: J. B. Lippincott 1965.
Engel, W. K.:Histochemistry of neuromuscular disease — significance of muscle fiber types. Neuromuscular Diseases. In Proceedings of the VIII International Congress of Neurology, Vienna, Austria. Excerpta med. (Amst.), Sect. II, 67 (1965).
Engel, W. K.:Chemocytology of striated annulets and sarcoplasmic masses in myotonic dystrophy. J. Histochem. Cytochem. 10, 229 (1962).
Lapresle, J., M. Fardeau, and M. Milhaud: Etude des ultrastructures dans les dystrophies muscularies progressives. In Proceedings of the Vth International Congress of Neuropathologie, Zurich, Switzerland. Excerpta med. (Amst.). (In press) 1966.
Hogenhuis, L. A. H., and W. K. Engel: Histochemistry and cytochemistry of experimentally denervated guinea pig muscle. I. Histochemistry. Acta anat. (Basel) 60, 39 (1965).
Engel, W. K., M. H. Brooke, and P. G. Nelson: Histochemical studies of denervated or tenotomized cat muscle. Ann. N. Y. Acad. Sci. (In press) 1966.
Engel, W. K., M. H. Brooke, and P. G. Nelson: Mitochondrial aggregates in muscle disease. J. Histochem. Cytochem. 12, 46 (1964).
Engel, W. K., M. H. Brooke, and P. G. Nelson: Muscle target fibers — a newly recognized sign of denervation. Nature (Lond.) 191, 389 (1961).
Engel, W. K., M. H. Brooke, and P. G. Nelson: The multiplicity of pathologic reactions of human skeletal muscles. In Proceedings of the Vth International Congress of Neuropathology, Zurich, Switzerland. Excerpta med. (Amst.), Sect. (In press) 1966.
Shy, G. M., and K. R. Magee: A new congenital non-progressive myopathy. Brain 79, 610 (1956).
Engel, W. K., J. B. Foster, B. P. Hughes, H. E. Huxley, andR. Mahler: Central core disease — an investigation of a rare muscle cell abnormality. Brain 84, 167 (1961).
Brooke, M. H., and W. K. Engel: The histological diagnosis of neuromuscular diseases: A review of 79 biopsies. Arch. phys. Med. Rehab. 47, 99 (1966).
Greenfield, J. G., G. M. Shy, E. C. Alvord, and L. Berg: An Atlas of Muscle Pathology in Neuromuscular Diseases. Edinburg and London: E. & S. Livingston 1957.
Coers, C., and A. L. Woolf. The Innervation of Muscle. Oxford: Blackwell 1959.
Winer, N., J. M. Martt, J. E. Somers, L. Wolcott, H. E. Dale, and T. W. Burns: Induced myotonia in man and goat. J. Lab. clin. Med. 66, 758 (1965).
Somers, J. E., and N. Winer: Neurology (Minneap.). (In press) 1966.
Engel, W. K., and M. H. Brooke: Muscle Biopsy as a Clinical Diagnostic Aid. In Recent Advances in Neurological Diagnostic Methods, 13th Annual Scientific Meeting of the Houston Neurological Society. W. S. Fields, Ed. Springfield, Ill.: Charles C. Thomas 1966. (In press).
Fardeau, M., J. Lapresle, and M. Milhaud: Contribution a l’etude des lesions elementaires du muscle squelettique:ultrastructure des masses sarcoplasmiques laterales (observees dans un cas de dystrophic myotonique). C. R. Soc. Biol. (Paris) 159, 15 (1965).
Milhaud,M., M. Fardeau, and J. Lapresle: Contribution a l’etude des lesions elementaires du muscle squelettique: ultrastructure des fibres annulaires (observees dans la dystrophic myotonique). C. R. Soc. Biol. (Paris) 158, 2274 (1964).
Editor information
Rights and permissions
Copyright information
© 1966 Springer-Verlag, Berlin · Heidelberg
About this chapter
Cite this chapter
Engel, W.K., Brooke, M.H. (1966). Histochemistry of the Myotonic Disorders. In: Kuhn, E. (eds) Progressive Muskeldystrophie Myotonie · Myasthenie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-92920-5_27
Download citation
DOI: https://doi.org/10.1007/978-3-642-92920-5_27
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-92921-2
Online ISBN: 978-3-642-92920-5
eBook Packages: Springer Book Archive