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Biochemical Aspects of Excitation of Protein Secretion in Pancreas

  • Lowell E. Hokin
  • Mabel R. Hokin
Conference paper

Abstract

Studies over the past several years have indicated that when secretion is stimulated in a variety of endocrine and exocrine glands there is an increased incorporation of labeled precursors into certain phospholipids (see reviews [5, 6, 8–15]). The phospholipids chiefly affected are phosphatidyl inositol and phosphatidic acid, although certain of the other phosphatides may be affected in certain tissues. Kinetic studies have indicated that the phospholipid effects in different glands are probably not the same phenomenon. For example, in the salt gland the changes in phosphatidyl inositol and phosphatidic acid are quite different than in the pancreas and appear to serve different functions. The changes in the salt gland have been described elsewhere [7,14–16]. In this presentation we shall confine our discussion primarily to the changes in phospholipid metabolism on stimulating protein secretion in the pancreas.

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Copyright information

© Springer-Verlag · Berlin · Heidelberg 1965

Authors and Affiliations

  • Lowell E. Hokin
    • 1
  • Mabel R. Hokin
    • 1
  1. 1.MadisonUSA

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