Zusammenfassung
Seit einigen Jahren häufen sieh die Hinweise, dass zwischen Kindern mit ADS/ADHS und gesunden Kindern vielfältige neurobiologische Unterschiede bestehen. Demnach ist ADS/ADHS nicht nur mit genetischen Veränderungen, sondern auch mit strukturellen und funktionellen Gehirnanomalien und neuropsychologischen Auffälligkeiten assoziiert.
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Literatur
Alexander GE et al. (1986) Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annu Rev Neurosci 9: 357–81
Zametkin AJ, Rapoport JL (1987) Neurobiology of attention deficit disorder with hyperactivity: where have we come in 50 years? J Am Acad Child Adolesc Psychiatry 26 (5): 676–86
Faraone SV et al. (2000) Toward guidelines for pedigree selection in genetic studies of attention deficit hyperactivity disorder. Genet Epidemio 18 (1): 1–16
Swanson JM et al. (2000) Dopamine genes and ADHD. Neurosci Biobehav Rev 24 (1): 21–5
Curran S et al. (2001) Association study of a dopamine transporter polymorphism and attention deficit hyperactivity disorder in UK and Turkish samples. Mol Psychiatry 6 (4): 425–8
Moll G, Rothenberger A (2000) in Förstl (Hrsg), Klinische Neuro-Psychiatrie, 150–90; Thieme, Stuttgart
Rubia K et al. (2001) Neuropsychological analyses of impulsiveness in childhood hyperactivity. Br J Psychiatry 179:138–43
Sieg KG et al. (1995) SPECT brain imaging abnormalities in attention deficit hyperactivity disorder. Clin Nucl Med 20(1): 55–60
Banaschewski T, Rothenberger A (2001) Berner Schriftenreihe 3: 47–67
Rubia K et al. (1999) Hypofrontality in attention deficit hyperactivity disorder during higher-order motor control: a study with functional MRl. Am J Psychiatry 156 (6): 891–6
Rothenberger A, Schmidt MH (2000) Die Funktion des Frontalhirns und der Verlauf psychischer Störungen. Lang, Frankfurt
Bush G et al. (1999) Anterior cingulate cortex dysfunction in attention-deficit/hyperactivity disorder revealed by fMRl and the Counting Stroop. Biol Psychiatry 45 (12): 1542–52
Moll GH et al. (2000) Deficient intracortical inhibition in drug-naive children with attention-deficit hyperactivity disorder is enhanced by methylphenidate. Neurosci Letters 284: 121–5
Kuperman S et al. (1990) Neuroimaging in child and adolescent psychiatry. J Am Acad Child Adolesc Psychiatry 29 (2): 159–72
Michelson D et al. (2002) Once-daily atomoxetine treatment for children and adolescents with attention deficit hyperactivity disorder: a randomized, placebo-controlled study. Am J Psychiatry 159: 1896–901
Avery RA et al. (2000) The alpha-2A-adrenoceptor agonist, guanfacine, increases regional cerebral blood flow in dorsolateral prefrontal cortex of monkeys performing a spatial working memory task. Neuropsychopharma- col 23 (3): 420–9
Manor I et al. (2001) Family-based association study of the serotonin transporter promoter region polymorphism (5-HTTLPR) in attention deficit hyperactivity disorder. Am J Med Genet 105 (1): 91–5
Himelstein J et al. (2000) The neurobiology of attention-deficit hyperactivity disorder. Front Biosci 5: D461–78
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Rothenberger, A., Banaschewski, T., Uebel, H. (2003). Neurobiologische Grundlagen eines pathophysiologischen Erklärungsmodells. In: Schulte-Markwort, M., Zinke, M. (eds) ADS/ADHS Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-92473-6_4
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DOI: https://doi.org/10.1007/978-3-642-92473-6_4
Publisher Name: Springer, Berlin, Heidelberg
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