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Individual Variation of Response to Drugs

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Book cover General Pharmacology

Part of the book series: Handbuch der Experimentellen Pharmakologie ((HDBEP,volume 4))

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Abstract

Methods of Measurement of Individual Variation. One of the most familiar facts in medical practice is that no two persons respond in exactly the same manner to drugs. The use of biological methods for standardising drugs has necessitated the measurement of the extent and distribution of this individual variation in response to drugs, and in consequence a large literature has accumulated. Estimations of the distribution of individual variation of populations in respect of response to drugs are based on characteristic curves, which relate the dosage or concentration of a drug with the percentage of a population showing some selected response. The response which is usually chosen is death, but any other response can be used, provided that it permits the division of the population into two classes, those responding and those which fail to respond. In some cases the individual variation in response to drugs is distributed according to the normal curve of error, but in many cases skew distributions occur which cover very wide ranges of concentration.

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Authors and Affiliations

  1. Edinburgh, UK

    A. J. Clark

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  1. A. J. Clark
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© 1937 Verlag von Julius Springer

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Clark, A.J. (1937). Individual Variation of Response to Drugs. In: General Pharmacology. Handbuch der Experimentellen Pharmakologie, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-91463-8_15

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  • DOI: https://doi.org/10.1007/978-3-642-91463-8_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-89607-1

  • Online ISBN: 978-3-642-91463-8

  • eBook Packages: Springer Book Archive

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