Skip to main content
SpringerLink
Log in

Kinetics of Drug Action

  • Chapter
General Pharmacology

Part of the book series: Handbuch der Experimentellen Pharmakologie ((HDBEP,volume 4))

  • 199 Accesses

Abstract

Sources of Error in Kinetic Measurements. It is very easy to make fairly accurate measurements of the rate of action on a cell population of a particular concentration of drug (time-action curve) and from a series of such curves, which cover an adequate range of concentrations, the relation between concentration and the time until a selected action appears (time-concentration curve) can be determined.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bayliss, W. M.: Proc. roy. Soc. B. 84, 81 (1911).

    Article  Google Scholar 

  2. Noyes, A. A., and W. R. Whitney: Z. physik. Chem. 23, 689 (1897).

    CAS  Google Scholar 

  3. Noyes, A. A., and W. R. Whitney: Z. physik. Chem. 35, 283 (1900).

    Google Scholar 

  4. Brunner, E.: Z. anorg. u. allg. Chem. 28, 314 (1901).

    Google Scholar 

  5. Brunner, E.: Z. anorg. u. allg. Chem. 35, 23.

    Google Scholar 

  6. Brunner, E.: Z. anorg. u. allg. Chem. 37, 455 (1903).

    Google Scholar 

  7. Brunner, E.: Z. physik. Chem. 47, 56 (1906).

    Google Scholar 

  8. Penman: Chem. Soc. Trans. 73, 511 (1898).

    Article  Google Scholar 

  9. Clark, A. J.: The Mode of Action of Drugs and Cells. London: Arnold and Co. 1933.

    Google Scholar 

  10. Gann, J. A.: Kolloid-Beih. 8, 64 (1916).

    Google Scholar 

  11. Arrhenius, S.: Quantitative Laws in Biological Chemistry. London: Bell and Sons 1915.

    Book  Google Scholar 

  12. Gasser, H. S.: Physiologic. Rev. 10, 35 (1930).

    Google Scholar 

  13. Brunner, E.: Z. physik. Chem. 47, 56 (1906).

    Google Scholar 

  14. Davis, H. S., and G. S. Crandall: J. amer. chem. Soc. 52, 3757 (1930).

    Article  CAS  Google Scholar 

  15. Bernheim, F., and A. Gorfain: J. Pharmacol. Baltimore 52, 338 (1934).

    CAS  Google Scholar 

  16. Webster, M. D.: J. Pharmacol. Baltimore 53, 340 (1935).

    CAS  Google Scholar 

  17. Brown, G. L., and J. C. Eccles: J. of Physiol. 82, 211, 242 (1934).

    CAS  Google Scholar 

  18. Ing, H. R., and W. M. Wright: Proc. roy. Soc. B. 109, 337 (1932).

    Article  Google Scholar 

  19. Cooper, E. A.: Biochemic. J. 6, 362 (1912).

    CAS  Google Scholar 

  20. Harteidge, H., and F. J. W. Roughton: J. of Physiol. 62, 232 (1927).

    Google Scholar 

  21. Osterhout, W. J. V.: Erg. Physiol. 35, 967 (1933).

    Google Scholar 

  22. Brooks M. M.: Protoplasma 1, 305 (1926).

    Article  Google Scholar 

  23. Irwin, M.: J. gen. Physiol. 8, 147 (1925/26).

    Article  PubMed  CAS  Google Scholar 

  24. Hoagland, D. R., P. L. Hibbard and A. R. Davis: J. gen. Physiol. 10, 121 (1926/27).

    Article  PubMed  CAS  Google Scholar 

  25. Jacques, A. G., and W. J. V. Osterhout: J. gen. Physiol. 13, 695 (1929/30).

    Article  Google Scholar 

  26. Brooks, M. M.: Amer. J. Physiol. 76, 360 (1926).

    CAS  Google Scholar 

  27. Field, J., and S. M. Field: Proc. Soc. exper. Biol. a. Med. 29, 733 (1931).

    Google Scholar 

  28. Ludsgaard, E.: Biochem. Z. 220, 1 (1930).

    Google Scholar 

  29. Lundsgaard, E.: Biochem. Z. 217, 162 (1930).

    CAS  Google Scholar 

  30. Ghaffar, A.: Quart. J. exper. Physiol. 25, 61 (1935).

    CAS  Google Scholar 

  31. Lohmann, K.: Biochem. Z. 230, 444 (1931).

    Google Scholar 

  32. Clark, A. J., M. G. Eggleton and P. Eggleton: J. of Physiol. 75, 332 (1932).

    CAS  Google Scholar 

  33. Porodko, T. M.: Ber. dtsch. Bot. Ges. 44, 71 (1926).

    Google Scholar 

  34. Hill, A. V.: J. of Physiol. 39, 361 (1909).

    CAS  Google Scholar 

  35. Boehm, R.: Heffters Handb. exper. Pharmakol. 2, 187 (1920).

    Google Scholar 

  36. Boehm, R.: Arch. f. exper. Path. 63, 219 (1910).

    Google Scholar 

  37. Hartridge, H. and F. J. W. Roughtok: J. of Physiol. 62, 232 (1927).

    CAS  Google Scholar 

  38. Langenbeck, W.: Erg. Physiol. 35, 470 (1933).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Edinburgh, UK

    A. J. Clark

Authors
  1. A. J. Clark
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 1937 Verlag von Julius Springer

About this chapter

Cite this chapter

Clark, A.J. (1937). Kinetics of Drug Action. In: General Pharmacology. Handbuch der Experimentellen Pharmakologie, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-91463-8_12

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-91463-8_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-89607-1

  • Online ISBN: 978-3-642-91463-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation