Abstract
Changes discovered in serotonin (5-HT) metabolism during migraine attacks have focused attention on blood platelets, the main reservoir of 5-HT in the body. Several disturbances in platelet function were indeed observed in migraineurs, and two lines of thought emerged. In one, the platelet abnormality was thought to result from a circulating agent which causes 5-HT release. The activity of this agent was thought to be directly connected to the initiation of the migraine attack itself (e.g., through the release of other vasoactive substances), or the released 5-HT could act as an intermediate. This view was first suggested by Anthony and co-workers [1, 2]. We have shown that a plasmatic factor occurs during migraine attack which can initiate 5-HT release from platelets of normal subjects. The responses of migraineurs’ platelets were quite similar to those of controls [3].
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© 1985 Springer-Verlag Berlin Heidelberg
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Kruglak, L., Nathan, I., Korczyn, A.D., Zolotov, Z., Berginer, V., Dvilansky, A. (1985). Platelet Aggregability, Disaggregability, and Serotonin Uptake in Migraine. In: Pfaffenrath, V., Lundberg, PO., Sjaastad, O. (eds) Updating in Headache. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-88581-5_18
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DOI: https://doi.org/10.1007/978-3-642-88581-5_18
Publisher Name: Springer, Berlin, Heidelberg
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