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Tumormarker beim Mammakarzinom: Verlaufsbeobachtung, Therapiekontrolle und Prognose

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Tumormarker

Zusammenfassung

Brustkrebserkrankungen stehen zusammen mit Krebserkrankungen des Dickdarms und Enddarms an erster Stelle aller malignen Neoplasien bei Frauen (1) und machen etwa 42% aller Krebsfälle bei Frauen aus. Die Prognose bei Brustkrebs hat sich in den letzten Jahren dank effizienter adjuvanter endokriner und zytostatischer Therapieverfahren signifikant verbessert (2), und nicht zuletzt ist die Gesamtprognose aufgrund der Aufklärung breiter Bevölkerungskreise und dem Anhalten zur Selbstuntersuchung der Brust erheblich gebessert worden, da die Diagnose „Brustkrebs“ heute in überwiegendem Maße in frühen Tumorstadien gestellt wird (3).

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Literatur

  1. Becker N, Frentzel-Beyme R, Wagner G, (Hrsg) (1984) Krebsatlas. Springer Berlin, Heidelberg, Tokio, New York

    Google Scholar 

  2. Kaufmann M, Kubli F, Caffier H, Jonat W, Maass H (1985) Adjuvante Chemo-Hormontherapie des Mammakarzinoms. Dtsch Med Wschr 110: 1009–1010

    Article  PubMed  CAS  Google Scholar 

  3. Schmidt-Matthiesen H (1985) Das kleine Mammakarzinom, Med Welt 36: 688–692

    Google Scholar 

  4. Chu TM, Nemoto T (1973) Evaluation of carcinoembryonic antigen in human mammary carcinoma. JNCI 52: 1119–1122

    Google Scholar 

  5. Coombes R C, Powles TJ, Gazet JC, Fort HT, Sloane JP, Laurence PJR, Neville AM (1977) Biochemical markers in human breast cancer. Lancet I: 132–134

    Google Scholar 

  6. Lamerz K, Leonhardt A, Erhart H, Lieven Hv (1979) CEA as a monitor of metastatic breast cancer. In: Lehman FG(ed) Carcinoembryonic protein, chemistry, biology, clinical application Elsevier/North Holland Biomedical Press, Amsterdam Vol. II 139–145

    Google Scholar 

  7. Staab H-J, Ahlemann L M, Koch HL, Anderer F A (1980) Serial carcinoembryonic antigen ( CEA) determinations in the management of patients with breast cancer. Oncodev Biol Med 1: 151–160

    Google Scholar 

  8. Schlegel G, Lüthgens M, Eklund G, Björklund B (1981) Correlations between activity in breast cancer and CEA, TPA and eighteen common laboratory procedures and the improvement by the combined use of CEA and TPA. Tumor Diagn 2: 6–11

    Google Scholar 

  9. Anderson JM, Stimson WH, Gettinby G, Jhunjhunwala K, Burt RW (1979) Detection of micro metastases by pregnancy-associated a2-glycoprotein (PAG, a2PAG or PAM) and carcinoembryonic antigen ( CEA ). Eur J Cancer 15: 709–714

    Google Scholar 

  10. Haagensen DE, Manzoujian G, Holder WO, Kister SJ, Weels S A (1977) Evaluation of a breast cyst protein in the plasma of breast carcinoma patients. Ann Surg 185: 279–285

    Article  PubMed  Google Scholar 

  11. Carcinoembryonic antigen: Its role as a marker in the management of cancer. [National Institute of Health. Consensus Development Conference Statement.] (1981) Cancer Res 41: 2017–2018

    Google Scholar 

  12. Hilkens J, Hilger J, Buijs F, Hagemann PH, Schol D, van Doornewaard G, van der Tweel J (1981) Monoclonal antibodies against human milk fat globule membranes usefiul in carcinoma research. In: Peters, H. (ed), Pergamon Press Oxford, Protides of the biological fluids, Vol 31, pp 813–816

    Google Scholar 

  13. Ahlemann L M, Staab H J, Beusch P, Anderer F A (1984) CEA as an additional prognostic factor to the TNM. J Cancer Res Cln Oncol 107: (Suppl.) 101

    Google Scholar 

  14. Staab HJ (1985) Qualitätssicherung bei Tumormarkertesten: Eine Studie mit CA 19–9. In Greten H, Klapdor R (Hrsg) Neue tumorassoziierte Antigene, Georg-Thieme Stuttgart S 319–320

    Google Scholar 

  15. Staab HJ, Anderer F A, Hornung A, Stumpf E, Fischer R (1982) Doubling time of circulating CEA and its relation to survival of patients with recurrent colorectal cancer. Br J Cancer 46: 773–781

    Article  PubMed  CAS  Google Scholar 

  16. Staab HJ, Anderer FA, Stumpf E, Hornung A, Fischer R, Kieninger G (1985) Eighty-four potential second-look-operations based on sequential carcinoembryonic antigen determinations and clinical investigations in patients with recurrent gastrointestinal cancer. Am J Surg 149: 198–204

    Article  PubMed  CAS  Google Scholar 

  17. Lüthgens M, Schlegel G (1981) Verlaufskontrolle mit Tissue Polypeptide Antigen und Carcinoembryonalem Antigen in der radioonkologischen Nachsorge und Therapie. Tumor Diagn 2: 179–188

    Google Scholar 

  18. Madeddu G, Farris A, Casu AR, Saiu MA, Eriu R, Constanza C, Arras ML, Kampus S (1985) Diagnostic and prognostic value of TPA in breast cancer. Cancer Detect Prey 8: 47–52

    CAS  Google Scholar 

  19. Haagensen DE, Barry WF, McCook TA, Giannola J, Ammirata S, Week SA (1980) The value of serial plasma levels of carcinoembryonic antigen and gross cystic disease fluid protein in patients with breast carcinoma and osseous metastasis. Ann Surg 191: 599–602

    Article  PubMed  Google Scholar 

  20. Staab HJ, Brümmendorf T, Hornung A, Anderer FA, Kieninger G (1985) The validity of circulating tumor associated antigens CEA and CA 19–9 in primary diagnosis and followup of patients with gastrointestinal malignancies. Klin Wschr 63: 106–115

    Article  PubMed  CAS  Google Scholar 

  21. Chu TM, Murphy GP (1978) Carcinoembryonic antigen: Evaluation as a screening assay in non-cancer clinics. New York State Med J 51: 879–882

    Google Scholar 

  22. Staab HJ, Hornung A, Anderer FA, Kieninger G (1984) Klinische Bedeutung des zirkulierenden tumorassoziierten Antigens CA 19–9 bei Karzinomen des Verdauungstraktes. Dtsch Med Wschr 109: 1141–1147

    Article  PubMed  CAS  Google Scholar 

  23. Woo KK, Waalkes TP, Ahmann DL, Tormey DC, Gehrke CW, Olivero V T (1978) A quantitative approach to determining disease response during therapy using multiple biologic markers. Cancer 41: 1685–1703

    Article  PubMed  CAS  Google Scholar 

  24. Staab HJ, Ahlemann LM, Anderer FA, Hiesche K, Rodatz W (1981) Comparison of serum 132microglobulin and carcinoembryonic antigen ( CEA) in the follow-up of breast cancer patients. J Clin Chem Clin Biochem 19: 339–345

    Google Scholar 

  25. Kreienberg R, Möbus V (1985) Die Bedeutung von CA 12–5 im Vergleich zu anderen Tumormarkern beim Ovarialkarzinom. In: Greten H, Klapdor R, Hrsg, Neue tumorassoziierte Antigene, Georg Thieme Stuttgart S 197–202

    Google Scholar 

  26. Staab HJ (1984) Medizinisch-biologische Bedeutung des karzinoembryonalen Antigens (CEA): Klinische Studien und experimentelle Modelle. Editiones Roche, Hoffmann-La Roche, GrenzachWhylen.

    Google Scholar 

  27. Grant AG, Duke D (1981) Production of antibodies against antigens released from human pancreatic tumor xenografts. Br J Cancer 44: 388–395

    Article  PubMed  CAS  Google Scholar 

  28. Staab HJ, Anderer FA (1984) Antisera against circulating human tumor associated antigens. In: Peters H (ed) Pergamon Press Oxford. Protides of the biological fluids. Georg Thieme Stuttgart, Vol 31, pp 511–516

    Google Scholar 

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© 1987 Dr. Dietrich Steinkopff Verlag, GmbH & Co. KG, Darmstadt

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Staab, HJ., Zwirner, M., Ahlemann, L.M., Anderer, F.A. (1987). Tumormarker beim Mammakarzinom: Verlaufsbeobachtung, Therapiekontrolle und Prognose. In: Wüst, G. (eds) Tumormarker. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-642-88539-6_47

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  • DOI: https://doi.org/10.1007/978-3-642-88539-6_47

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-642-88540-2

  • Online ISBN: 978-3-642-88539-6

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