The Juxtaglomerular Apparatus — History of a Concept
Nearly a century ago, Golgi (1889) described the essential components of the anatomical unit which is known today as the juxtaglomerular apparatus (JGA). He showed that the ascending limb of Henle’s loop regularly returns to the original renal corpuscle and attaches itself precisely to the point where the afferent arteriole enters and the efferent arteriole exits the glomerular hilus (Fig.1.1). Shortly thereafter, Tigerstedt and Bergman (1898) discovered the pressor-active principle of the kidney, which they named renin. Many years passed before Ruyter (1925) described a new granulated cell type in the media of the afferent glomerular arteriole and Goormaghtigh (1937, 1939) established the connection between the earlier observations of Golgi and those of Tigerstedt and Bergman by the proposal that renin may be elaborated by these cells.
KeywordsIschemia Angiotensin Renin Aldosterone Angiotensinogen
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