The Combined Effects of Different Evolutionary Forces

  • Albert Jacquard
Part of the Biomathematics book series (BIOMATHEMATICS, volume 5)


In the earlier chapters of this book we have examined in turn the consequences of dropping each of the six conditions for the establishment of Hardy-Weinberg equilibrium. We have thus approached a little closer to the real conditions under which a population transmits its genes to the next generation. However, in any real population, it is clear that many different factors will all act at the same time: the generations will often overlap, rather than being separate, migration may occur, so that each group is in communication with other groups, new genes will arise by mutation, selection will occur, and may be very strong in favour of certain genes, mating will not really take place at random, and, finally, the population will not be of infinite size, so that gene frequencies will be subject to random fluctuations.


Effective Population Size Gene Frequency Asymptotic Distribution Evolutionary Force Mutational Load 
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Further Reading

  1. Cavalli-Sforza, L.L., Zei, G.: Experiments with an artificial population. Proc. III Int. Congress Hum. Genet., p. 473–478. Baltimore: Johns Hopkins Press 1966.Google Scholar
  2. Crow, J. F., Maruyama, T.: The number of neutral alleles maintained in a finite geographically structured population. Theoret. Pop. Biol. 2, 437–453 (1971).CrossRefGoogle Scholar
  3. Li, C.C.: The way the load ratio works. Amer. J. Hum. Genet. 15, 316–321 (1963).Google Scholar
  4. Morton, N.E.: The mutational load due to detrimental genes in man. Amer. J. Hum. Genet. 12, 348–364 (1960).Google Scholar
  5. Sanghvi, L.D.: The concept of genetic load: a critique. Amer. J. Hum. Genet. 15, 298–309 (1963).Google Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1974

Authors and Affiliations

  • Albert Jacquard
    • 1
  1. 1.Institut National d’Etudes DémographiquesParisFrance

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