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Sex hormone secretion by the adrenal cortex

  • Chapter
The Adrenocortical Hormones

Part of the book series: Handbuch der Experimentellen Pharmakologie ((HEP,volume 14 / 1))

Abstract

The production of sex hormones by congenital hyperplasias or malignancies of the adrenal cortex has long been recognized as suggestive of a biochemical relationship between the adrenal cortex and the gonads. The embryological origin of these tissues from adjacent portions of the dorsal mesentery provided a plausible background for similarities (Poll 1900, Politzer 1937, Gruenwald 1942). Present developments of enzyme chemistry point toward a qualitative similarity of the biosynthetic systems in all tissues forming steroid hormones (Samuels 1958). Thus, the concept is emerging that these tissues have, to a great degree, the same set of biosynthetic enzymes, but differ in the relative activities or amounts of different individual enzymes. In this view, the biochemical behavior of malignancies need not involve the presence of “embryonic cell rests” of another tissue, or the de novo formation of new enzymes, but simply an abnormally high concentration of certain enzymes normally present in small amounts. In this chapter, we shall summarize the evidence regarding the nature and amount of sex hormones secreted by the adrenal cortex, with primary emphasis on physiological rather than malignant states.

Supported in part by research grants (numbers H-2414, A-2609 and A-180) from the National Heart Institute and the Arthritis and Metabolic Diseases Division of the United States Public Health Service. The chapter was completed late in 1959, but a few additions were made on the proof in the Spring of 1961.

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Authors
  1. Evelyn Howard
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  2. Claude J. Migeon
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Editors and Affiliations

  1. Department of Pathology and Anatomy, Albert Einstein College of Medicine, New York 61, New York, USA

    Helen Wendler Deane Ph.D.

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© 1962 Springer-Verlag Berlin Heidelberg

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Howard, E., Migeon, C.J. (1962). Sex hormone secretion by the adrenal cortex. In: Deane, H.W. (eds) The Adrenocortical Hormones. Handbuch der Experimentellen Pharmakologie, vol 14 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-88385-9_5

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  • DOI: https://doi.org/10.1007/978-3-642-88385-9_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-88387-3

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