Zusammenfassung
Plasmazelldyskrasien umfassen mehrere Formen unkontrollierter, exzessiver Wucherungen bestimmter Zellklone. In den meisten Fällen werden diese Proliferationen von der Bildung großer Mengen von monoklonalen Gammaglobulinen begleitet, die den bekannten Immunglobulinen IgG, IgA, IgM, IgD und IgE zugehören. Diese „Paraproteine“ als Folge der monoklonalen Gammopathien kommen beim multiplen Myelom meistens in der IgG-, IgA- und IgD- sowie bei der Makroglobulinämie Waldenström in der IgM-Klasse vor.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
Literatur
Aisenberg AC (1978) Lymphoma, leukemia, and Hodgkin’s disease. In:Samter M (ed) Immunological diseases. Little, Brown & Co, Boston, pp 530–547.
Alexanian R, Migliore PJ (1970) Normal immunoglobulins in multiple myeloma:Effect of melphalan chemotherapy. J Lab Clin Med 75:225.
Alexanian R, Haut AU, Kahn AV, Lane M, McKelvey EM, Migliore PJ, Stuckey WJ, Wilson HE (1969) Treatment of multiple myeloma. Combination chemotherapy with different melphalan dose regimes. JAMA 208:1680.
Axelsson U, Hällen J (1972) A population study on monoclonal gammopathy. Follow-up after 5½ years on 64 subjects detected by electrophoresis on 6995 sera. Acta Med Scand 191:111.
Axelsson U, Bachmann R, Hällen J (1966) Frequency of pathological proteins (M-components) in 6995 sera from an adult population. Acta Med Scand 179:235.
Bach GL (1974) Knochenveränderungen bei Paraproteinämien. Aerztl Praxis 26:2724.
Bach GL (1979) Knochenveränderungen bei Paraproteinämien. Verh Dtsch Ges Inn Med 85:342.
Ballard HS, Hamilton LM, Marcus AJ, Illes CH (1970) A new variant of heavy-chain disease (μ-chain disease). N Engl J Med 282:1060.
Bernhard GC, Hensley GT (1969) Amyloid arthropathy. Arthritis Rheum 12:444.
Bonhomme J, Seligmann M, Mihaesco C, Clauvel JP, Danon F, Brouet JC, Bouvry P, Martine J, Clerc M (1974) μ-chain disease in an African patient. Blood 43:485.
Brocher JEW (1959) Die Wirbelsäulenleiden und ihre Differentialdiagnose. Thieme, Stuttgart, S 412.
Cohen AS, Canoso JJ (1975) Rheumatological aspects of amyloid disease. Clin Rheum Dis 1:149.
Dammacco F, Bonomo L, Franklin EC (1974) A new case of μ-heavy chain disease:Clinical and immunological studies. Blood 43:713.
Defronzo RA, Humphrey RL, Wright JR, Cooke CR (1975) Acute renal failure in multiple myeloma. Medicine (Baltimore) 54:209.
Ellman LL, Block KJ (1968) Heavy-chain disease:Report of a seventh case. N Engl J Med 278:1195.
Engle RL, Wallis LA (1969) Immunoglobinopathies. Thomas, Springfield.
Farhangi M, Osserman EF (1973) The treatment of multiple myeloma. Semin Hematol 10:149.
Forte FA, Prelli F, Yount WJ, Jerry LM, Kochwa S, Franklin EC, Kunkel HG (1970) Heavy chain disease of the μ (M) type:Report of the first case. Blood 37:137.
Frangione B, Franklin EC (1973) Heavy chain diseases:Clinical features and molecular significance of the disordered immunoglobulin structure. Semin Hematol 10:53.
Franklin EC (1975) μ-chain disease. Arch Intern Med 135:71.
Franklin EC, Frangione B (1975) Structural variants of human and murine immunoglobulins. Contemp Top Mol Immunol 4:89.
Franklin EC, Lowenstein J, Bigelow B, Meltzer M (1964) Heavy chain disease:A new disorder; report of the first case. Am J Med 37:332.
Frey-Wettstein M (1976) Myelomtherapie. Schweiz Med Wochenschr 106:773.
Goldberg A, Brodsky I, McCarty D (1964) Multiple myeloma with paramyloidosis presenting as rheumatoid disease. Am J Med 37:653.
Goldberg LS, Fischer R, Castronova EA, Calabro JJ (1969) Amyloid arthritis associated with Waldenström’s macroglobulinemia. N Engl J Med 281:256.
Hoogstraten B, Shsehe PR, Cuttner J, Cooper T, Kyle RA, Oberfield RA, Townsend SR, Hartley JB, Hayes DM, Costa G, Holland JF (1967) Melphelan in multiple myeloma. Blood 30:74.
Imhof JW, Baars H, Verloop MC (1959) Clinical and hematological aspects of macroglobulinemia Waldenström. Acta Med Scand 163:349.
Isobe T, Osserman EF (1974) Plasma cell dyscrasia associated with the production of incomplete (deleted) IgG molecules, gamma heavy chains, and free λ-chains containing carbohydrate:Description of the first case. Blood 43:505.
Jancelewicz Z, Takatsuki K, Sugai S, Pruzanski W (1975) IgD multiple myeloma:Review of 133 cases. Arch Intern Med 135:87.
Jesserer H (1971) Knochenkrankheiten. Urban & Schwarzenberg, München Berlin Wien.
Kappeler R, Krebs A, Riva G (1958) Klinik, der Makroglobulinämie Waldenström. Helv Med Acta 25:45.
Korst DR, Clifford GO, Fowler WM, Louis J, Will J, Wilson HE (1964) Multiple myeloma. II. Analysis of cyclophosphamide therapy in 165 patients. JAMA 189:156.
Lee SL, Rosner F, Ruberman W, Glasberg S (1971) μ-chain disease. Ann Intern Med 75:407.
Mill WB (1975) Radiation therapy in multiple myeloma. Radiology 115:175.
Osserman EF (1959) Plasma-cell myeloma. II. Clinical aspects. N Engl J Med 261:952.
Osserman EF (1978) Multiple myeloma and related plasma cell dyscrasias. In:Samter M (ed) Immunological diseases. Little, Brown & Co, Boston, pp 499–529.
Osserman EF, Takatsuki K (1963) Plasma cell myeloma:Gamma globulin synthesis and structure. Medicine (Baltimore) 42:357.
Osserman EF, Takatsuki K (1964) Clinical and immunological studies of four cases of heavy (H2) chain disease. Am J Med 37:351.
Paul LW, Juhl JH (1967) Essentials of roentgen diagnosis of the skeletal system. Harper & Row, New York Evanston London, pp 160–161.
Pitman FE, Tripathy K, Isobe T, Bolanos DM, Osserman EF, Pitman JC, Lotero HR, Duque EE (1975) IgA heavy chain disease. Am J Med 58:425.
Rambaud JC, Bognel C, Prost A, Bernier JJ, LeQuentrec Y, Lambling A, Danon F, Hurez D, Seligmann M (1968) Clinico-pathological study of a patient with “Mediterranean” type of abdominal lymphoma and a new type of IgA abnormality (“α-chain disease”). Digestion 1:321.
Rappaport H (1966) Tumors of the hematopoietic system. In:Atlas of tumor pathology, Sec 3, fasc 8. Armed Forces Institute of Pathology, Washington, DC.
Ritzmann SE, Levin WC (1969) Polyclonal and monoclonal gammopathies. In:Dettelbach HR, Ritzmann SE (eds) Lab Synopsis, Vol 2. Hoechst Pharmaceuticals, Woodbury, NY, pp 9–38.
Salmon SE, Durie BGM, Hamburger AW (1978) A new basis for treatment of multiple myeloma. Schweiz Med Wochenschr 108:1568.
Seligmann M (1975) α-chain disease:Immunoglobulin abnormalities, pathogenesis and current concept. Br J Cancer 31:356.
Seligmann M, Rambaud JC (1969) IgA abnormality in abdominal lymphoma (α-chain disease). Isr J Med Sci 5:151.
Seligmann M, Danon F, Hurez D, Mihaesco E, Preud’homme JL (1968) α-chain disease:A new immunoglobin abnormality. Science 162:1396.
Snapper I, Turner LB, Moskovitz HL (1953) Multiple myeloma. Grune & Stratton, New York.
Solomon A, Kunkel HG (1967) A “monoclonal” type, low molecular weight protein related to M-macroglobulin. Am J Med 42:958.
Sonntag RW (1978) Prognose und Therapie des multiplen Myeloms. Schweiz Med Wochenschr 108:1247.
Spengler GA, Weber RM, Wyttenbach H von, Huser HJ (1978) Lymphoproliferative Erkrankungen mit kleinmolekularer (monomerer) IgM-Paraproteinämie. Schweiz Med Wochenschr 108:1605.
Tsuji T (1970) Heavy chain (Fc fragment) disease. Immunochemical reactions of the first case in Japan and the incorporation of 14C-amino acids into the protein in vitro. Acta Haematol Jpn 33:89.
Waldenström J (1958) Die Makroglobulinämie. Ergeb Inn Med Kinderheilkd 586.
Waldenström J (1970) Diagnosis and treatment of multiple myeloma. Grune & Stratton, New York.
Weitzel RA (1958) Carcinoma coexistent with malignant disorders of plasma cells. Cancer 11:546.
Welton J, Walker SR, Sharp GC, Herzenberg LA, Wistar R, Creger WP (1968) Macroglobulinemia with bone destruction. Am J Med 44:280.
Zawadzki Z, Benedek TG, Ein D, Easton JM (1969) Rheumatoid arthritis terminating in heavy chain disease. Ann Intern Med 70:335.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1983 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Bach, G.L. (1983). Wirbelsäulenerkrankungen bei Paraproteinämien. In: Aufdermaur, M., et al. Rheumatologie C. Handbuch der inneren Medizin, vol 6 / 2 / C. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-88228-9_9
Download citation
DOI: https://doi.org/10.1007/978-3-642-88228-9_9
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-88229-6
Online ISBN: 978-3-642-88228-9
eBook Packages: Springer Book Archive