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Inhibition of Insulin Specific Protease by Proteinase Inhibitors from the Snail (Helix pomatia)

  • J. S. Brush
  • H. Tschesche
Conference paper
Part of the Bayer-Symposium book series (BAYER-SYMP, volume 5)

Abstract

The enzyme, insulin specific protease, described in the rat diaphragm [1] and partially purified from rat muscle [2] and liver [3] very rapidly cleaves insulin with considerable specificity [2, 3] at physiological concentrations, optimally at pH 7.5. The identification and partial purification of polypeptide inhibitors of the enzyme in the α1-globulin fraction of human plasma has recently been described [4].

Keywords

Partial Purification Helix Pomatia Insulin Degradation Considerable Specificity Inhibitor Fraction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • J. S. Brush
    • 1
  • H. Tschesche
    • 2
  1. 1.Department of BiochemistryUniversity of Tennessee Medical Units and the Veterans Administration HospitalMemphisUSA
  2. 2.Lehrstuhl für Organische Chemie und BiochemieOrganisch-Chemisches Laboratorium der Technischen Universität MünchenMunichFed. Rep. Germany

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