Inhibition of Insulin Specific Protease by Proteinase Inhibitors from the Snail (Helix pomatia)

  • J. S. Brush
  • H. Tschesche
Conference paper
Part of the Bayer-Symposium book series (BAYER-SYMP, volume 5)


The enzyme, insulin specific protease, described in the rat diaphragm [1] and partially purified from rat muscle [2] and liver [3] very rapidly cleaves insulin with considerable specificity [2, 3] at physiological concentrations, optimally at pH 7.5. The identification and partial purification of polypeptide inhibitors of the enzyme in the α1-globulin fraction of human plasma has recently been described [4].


Sucrose Albumin Iodine Polypeptide Trypsin 


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Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • J. S. Brush
    • 1
  • H. Tschesche
    • 2
  1. 1.Department of BiochemistryUniversity of Tennessee Medical Units and the Veterans Administration HospitalMemphisUSA
  2. 2.Lehrstuhl für Organische Chemie und BiochemieOrganisch-Chemisches Laboratorium der Technischen Universität MünchenMunichFed. Rep. Germany

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