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Proteinase Inhibitors of Microbial Origin A Review

  • W. Wingender
Part of the Bayer-Symposium book series (BAYER-SYMP, volume 5)

Abstract

Naturally occurring enzyme inhibitors have been searched for in tissues of animals and plants for many decades and there are excellent reviews on proteoly-tic enzyme inhibitors [1, 2]. The possibility of the existence of enzyme inhibitors of microbial origin, however, had been suggested recently by the fact that microorganisms are able to produce antibiotics, which inhibit enzyme reactions necessary for growth and multiplication [3]. Investigations of microorganisms as producers of substances with a capacity of inhibiting proteases have until recent years been relatively few. This is rather surprising, since proteolytic enzymes outside of the microbial cells are thought to be harmful to the organisms and a probable protection mechanism against these proteolytic enzymes by production of proteinase inhibitors must be considered. It is only during the past few years that sufficient progress has been made to bring this concept into the realm of practical significance.

Keywords

Culture Filtrate Microbial Origin Amino Acid Ester Isovaleric Acid Potent Competitive Inhibitor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Kassel, B.: Methods Enzymol. 19, 839–906 (1970).CrossRefGoogle Scholar
  2. 2.
    Vogel, R., Trautschold, I., Werle, E.: Natural Proteinase-Inhibitors. New York-London: Academic Press 1968. Natärliche Proteinasen-Inhibitoren. Stuttgart: Thieme 1966.Google Scholar
  3. 3.
    Umezawa, H.: Enzyme Inhibitors of Microbial Origin. Baltimore-London-Tokyo: University Park Press 1972.Google Scholar
  4. 4.
    Hoeyen, T, Skulberg, A.: Nature (Lond.) 195, 922–923 (1962).CrossRefGoogle Scholar
  5. 5.
    Yamamoto, K., Hayashi, K.: Symp. Enzyme Chem. 18, 21–29 (1962).Google Scholar
  6. 6.
    Shimada, K., Matsushima, K.: J. agric. Chem. Soc. Japan 42, 325–329 (1968).Google Scholar
  7. 7.
    Brecher, A.S., Pugatch, R.D.: Experientia (Basel) 25, 251–252 (1969).CrossRefGoogle Scholar
  8. 8.
    Fossum, K.: Acta path, microbiol. scand., Sect. B 78, 755–759 (1970).Google Scholar
  9. 9.
    Torstensson, N.T.L., Jönsson, A.G.: Arch. Microbiol. 83, 63–70 (1972).CrossRefGoogle Scholar
  10. 10.
    Torstensson, N.T.L.: Arch. Microbiol. 91, 11–18 (1973).CrossRefGoogle Scholar
  11. 11.
    Aoyagi, T., Takeuchi, A., Matsuzaki, A., Kawamura, K., Kondo, S., Hamada, M., Maeda, K., Umezawa, H.: J. Antibiot. (Tokyo) 22, 283–286 (1969).CrossRefGoogle Scholar
  12. 12.
    Suda, H., Aoyagi, T., Hamada, M., Takeuchi, T., Umezawa, H.: J. Antibiot. (Tokyo) 25, 263–266 (1972).CrossRefGoogle Scholar
  13. 13.
    Umezawa, H., Aoyagi, T., Morishima, H., Kunimoto, S., Matsuzaki, M., Hamada, M., Takeuchi, T.: J. Antibiot. (Tokyo) 23, 425–427 (1970).CrossRefGoogle Scholar
  14. 14.
    Umezawa, H., Aoyagi, T., Morishima, H., Matsuzaki, M., Hamada, M., Takeuchi, T.: J. Antibiot. (Tokyo) 23, 259–265 (1970).CrossRefGoogle Scholar
  15. 15.
    Kondo, S., Kawamura, K., Iwanaga, J., H Amada, M., Aoyagi, T., Maeda, T., Takeuchi, T., Umezawa, H.: Chem. Pharm. Bull. (Tokyo) 17, 1896–1901 (1969).CrossRefGoogle Scholar
  16. 16.
    Kawamura, K., Kondo, S., Maeda, K., Umezawa, H.: Chem. Pharm. Bull. (Tokyo) 17, 1902–1909 (1969).CrossRefGoogle Scholar
  17. 17.
    Maeda, K., Kawamura, K., Kondo, S., Aoyagi, T., Takeuchi, T., Umezawa, H.: J. Antibiot. (Tokyo) 24, 402–404 (1971).CrossRefGoogle Scholar
  18. 18.
    Shimizu, B., Saito, A., Ito, A., Tokawa, K., Maeda, K., Umezawa, H.: J. Antibot. (Tokyo) 25, 515–523 (1972).CrossRefGoogle Scholar
  19. 19.
    Umezawa, S., Tatsuta, K., Fujimoto, K., Tsuchiya, T., Umezawa, H., Naganawa, H.: J. Antibiot. (Tokyo) 25, 267–270 (1972).CrossRefGoogle Scholar
  20. 20.
    Aoyagi, T., Morishima, H., Nishizawa, R., Kunimoto, S., Takeuchi, T., Umezawa, H.: J. Antibiot. (Tokyo) 25, 689–694 (1972).CrossRefGoogle Scholar
  21. 21.
    Morishima, H., Takita, T., Aoyagi, T., Takeuchi, T., Umezawa, H.: J. Antibiot. (Tokyo) 23, 263–265 (1970).CrossRefGoogle Scholar
  22. 22.
    Miyano, T., Tomiyasu, M., Iizuka, H., Tomisaka, S., Takita, T., Aoyagi, T., Umezawa, H.: J. Antibiot. (Tokyo) 25, 489–491 (1972).CrossRefGoogle Scholar
  23. 23.
    Nakamura, H., Morishima, H., Takita, T., Umezawa, H., Iitaka, Y.: J. Antibiot. (Tokyo) 26, 255–256 (1973).CrossRefGoogle Scholar
  24. 24.
    Aoyagi, T., Kunimoto, S., Morishima, H., Takeuchi, T., Umezawa, H.: J. Antibiot. (Tokyo) 24, 687–694 (1971).CrossRefGoogle Scholar
  25. 25.
    Aoyagi, T., Miyata, S., Nanbo, M., Kojima, F., Matsuzaki, M., Ishizuka, M., Takeuchi, T, Umezawa, H.: J. Antibiot. (Tokyo) 22, 558–568 (1969).CrossRefGoogle Scholar
  26. 26.
    Ito, A., Tokawa, K., Shimizu, B.: Biochem. Biophys. Res. Commun. 49, 343–349 (1972).PubMedCrossRefGoogle Scholar
  27. 27.
    O’connor Westerik, J., Wolfenden, R.: J. biol. Chem. 247, 8195–8197 (1972).Google Scholar
  28. 28.
    Kunimoto, S., Aoyagi, T., Morishima, H., Takeuchi, T., Umezawa, H.: J. Antibiot. (Tokyo) 25, 251–255 (1972).CrossRefGoogle Scholar
  29. 29.
    Fritz, H, Förg-Brey, B., Umezawa, H.: Z. physiol. Chem. 354, 1304–1306 (1973).CrossRefGoogle Scholar
  30. 30.
    Barrett, A.J., Dingle, J.T.: Biochem. J. 127, 439–441 (1972).PubMedGoogle Scholar
  31. 31.
    Dingle, J.T., Barrett, A.J., Poole, A.R.: Biochem. J. 127, 443–444 (1972).PubMedGoogle Scholar
  32. 32.
    Miller, R.P., Poper, C.J., Wilson, C.W., Devito, E.: Biochem. Pharmacol. 21, 2941–2944 (1972).PubMedCrossRefGoogle Scholar
  33. 33.
    Aoyagi, T., Yagisawa, Y., Kumagai, M., Hamada, M., Morishima, H., Takeuchi, T., Umezawa, H.: J. Antibiot. (Tokyo) 26, 539–541 (1973).CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • W. Wingender
    • 1
  1. 1.Biochemisches LaboratoriumBayer AGWuppertal 1Fed. Rep. Germany

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