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Elastase Inhibitors as Impurities in Commercial Preparations of Soybean Trypsin Inhibitor (Kunitz)

  • Conference paper
Proteinase Inhibitors

Part of the book series: Bayer-Symposium ((BAYER-SYMP,volume 5))

Abstract

We have recently shown that the activity of free or α2-macroglobulin-bound elastase is inhibited by Kunitz’s soybean trypsin inhibitor [1]. Our observation was in agreement with earlier studies indicating that STI is an elastase inhibitor [2–4]. We now report that this property can no longer been ascribed to pure STI since elastase inhibitors may contaminate commercial preparations of STI.

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Abbreviations

STI:

Kunitz's Soybean Trypsin Inhibitor

Boc-Ala-ONp:

N-t-butyloxycarbonyl-L-alanine-p-nitro-phenylester

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Author information

Authors and Affiliations

  1. Laboratoire de Chimie, Clinique Médicale A, Hópital Civil, 67005, Strasbourg, Cedex, France

    J. Bieth

  2. Laboratoire de Chimie biologique, Faculté de Pharmacie, Université Louis Pasteur, 67083, Strasbourg, Cedex, France

    J.-C. Frechin

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  1. J. Bieth
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  2. J.-C. Frechin
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Editor information

Editors and Affiliations

  1. Institut für Klinische Chemie und Klinische Biochemie, Universität München, 8000, Munich 2, Fed. Rep. Germany

    Hanz Fritz

  2. Organisch-Chemisches Laboratorium, Technischen Universität München, 8000, Munich 2, Fed. Rep. Germany

    Harald Tschesche

  3. Department of Biology, Brookhaven National Laboratory, Upton, NY, 11973, USA

    Lewis J. Greene

  4. Biochemisches Laboratorium, Bayer AG, 5600, Wuppertal 1, Fed. Rep. Germany

    Ernst Truscheit (Editor-in-Chief) (Editor-in-Chief)

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© 1974 Springer-Verlag

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Bieth, J., Frechin, JC. (1974). Elastase Inhibitors as Impurities in Commercial Preparations of Soybean Trypsin Inhibitor (Kunitz). In: Fritz, H., Tschesche, H., Greene, L.J., Truscheit, E. (eds) Proteinase Inhibitors. Bayer-Symposium, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-87966-1_36

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  • DOI: https://doi.org/10.1007/978-3-642-87966-1_36

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-87968-5

  • Online ISBN: 978-3-642-87966-1

  • eBook Packages: Springer Book Archive

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