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Studies on the Purification and Characterization of Boar Acrosin

  • Conference paper
Proteinase Inhibitors

Part of the book series: Bayer-Symposium ((BAYER-SYMP,volume 5))

Abstract

Mammalian fertilization requires that a sperm cell penetrates the ovum investments (Fig. 1). Penetration is aided by hydrolytic enzymes from the acrosome(a modified lysosome located on the anterior portion of the sperm head). Ejaculated sperm are unable to penetrate these layers until they have undergone a functional change in the female reproductive tract, a process referred to as capaci-tation [2, 3]. We believe capacitation involves the activation, release or exposure of the sperm acrosomal hydrolytic enzymes, as well as labilization of sperm membranes.

Supported in part by National Institutes of Health Contracts 69-2103 and 70-2147, National Institutes of Health Research Grant HD 05891 and Ford Foundation Research Grant 680-0805 A.

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Author notes

  1. K. L. Polakoski

    Present address: Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO, 63110, USA

Authors and Affiliations

  1. Reproduction Research Laboratory of the Biochemistry Department, University of Georgia, Athens, GA, 30602, USA

    K. L. Polakoski & W. L. Williams

Authors
  1. K. L. Polakoski
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  2. W. L. Williams
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Editor information

Editors and Affiliations

  1. Institut für Klinische Chemie und Klinische Biochemie, Universität München, 8000, Munich 2, Fed. Rep. Germany

    Hanz Fritz

  2. Organisch-Chemisches Laboratorium, Technischen Universität München, 8000, Munich 2, Fed. Rep. Germany

    Harald Tschesche

  3. Department of Biology, Brookhaven National Laboratory, Upton, NY, 11973, USA

    Lewis J. Greene

  4. Biochemisches Laboratorium, Bayer AG, 5600, Wuppertal 1, Fed. Rep. Germany

    Ernst Truscheit (Editor-in-Chief) (Editor-in-Chief)

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© 1974 Springer-Verlag

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Polakoski, K.L., Williams, W.L. (1974). Studies on the Purification and Characterization of Boar Acrosin. In: Fritz, H., Tschesche, H., Greene, L.J., Truscheit, E. (eds) Proteinase Inhibitors. Bayer-Symposium, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-87966-1_17

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  • DOI: https://doi.org/10.1007/978-3-642-87966-1_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-87968-5

  • Online ISBN: 978-3-642-87966-1

  • eBook Packages: Springer Book Archive

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