Abstract
A suitable inducer of cell differentiation in the mammalian host stimulates a complex series of events which often includes the division of cells and the synthesis of specialized protein. According to current concepts specialized cell function requires the activation of information stored in a latent form in the genome of the cell for the synthesis of new RNAs and new protein. Thus, if the differentiated response is of sufficient magnitude and if the assay is of adequate sensitivity, one might detect new RNA synthesis in differentiating cells. Cells which differentiate to form proteins which are distinguishable from one another may form detectably different species of RNA.
Supported by U. S. Public Health Service grant AI 06852–03.
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References
Attardi, E., H. Parnas, M-I. H. Hwang, B. Attardi (1966). Giant-size rapidly labeled nuclear ribonucleic acid and cytoplasmic messenger ribonucleic acid in immature duck erythrocytes. J. Mol. Biol., 20: 145.
Bautz, E. K. F., and E. Reilly (1966). Gene-specific messenger RNA: Isolation by the deletion method. Science, 151:328.
Burnet, M. (1959). “The clonal selection theory of acquired immunity.” Nashville: Vanderbilt University Press.
Bussard, A. E., and M. Lurie (1967). Primary antibody response in vitro in peritoneal cells. J. Exptl. Med., 125:873.
Church, R. B., and B. J. McCarthy (1967a). Ribonucleic acid synthesis in regenerating and embryonic liver. I. The synthesis of new species of RNA during regeneration of mouse liver after partial hepatectomy. J. Mol. Biol., 23:459.
Church, R. B., and B. J. McCarthy (1967b). Ribonucleic acid synthesis in regenerating and embryonic liver. II. The synthesis of RNA during embryonic liver development and its relationship to regenerating liver. J. Mol. Biol., 23:477.
Cohen, E. P. (1967a). Conversion of nonimmune cells into antibody-forming cells by RNA. Nature, 213:462.
Cohen, E. P. (1967b). The appearance of new species of RNA in the mouse spleen after antigen. Proc. Nat. Acad. Sci., 57:673.
Dreyer, W. J., and J. C. Bennett (1965). The molecular basis of antibody formation: A paradox. Proc. Nat. Acad. Sci., 54:864.
Edelman, E. M., and J. A. Gailly (1967). Somatic recombination of duplicated genes: a hypothesis on the origin of antibody diversity. Proc. Nat. Acad. Sci., 57:353.
Hood, L. E., W. R. Gray, W. J. Dreyer (1966). On the mechanism of antibody synthesis: A species comparison of 2-chains. Proc. Nat. Acad. Sci. (U. S.), 55:826.
Hoyer, B. H., E. T. Bolton, B. J. McCarthy, and R. B. Roberts (1965). The evolution of polynucleotides in Evolving Genes and Proteins, eds. V. Bryson and H. J. Vogel, New York: Academic Press, p. 581.
Ingram, V. (1961). Gene evolution and the hemoglobins. Nature, 189:704.
Juhasz, A., and B. Rose (1963). Studies on antibody formation. I. Relationship between nucleic acids and antibody synthesis in the primary response in the rat. Can. J. Biochem., 41:2983.
Jukes, T. H. (1966). Molecules and evolution. Columbia University Press, New York and London, pp. 153–190.
Koros, A. M., H. Fuji, and N. K. Jerne (1966). Kinetics of proliferation of clones of antibody-producing cells. Abstract number 650 in Abstracts of the 50th annual meeting of the Federation of American Societies for Experimental Biology.
Lederberg, J. (1959). Genes and antibodies. Science, 129:1649.
Mach, B., and P. Vassalli (1965). Biosynthesis of RNA in antibody-producing tissues. Proc. Nat. Acad. Sci., 54:975.
Marmur, J. (1961). A procedure for the isolation of deoxyribonucleic acid from microorganisms. J. Mol. Biol., 3:208.
Pinchuck, P. (1967). Personal communication. We thank Dr. Pinchuck for supplying us with the polymers.
Putnam, F. W., T. Shinoda, K. Titani, and M. Wikler (1967). Immunoglobulin structure: Variation in amino acid sequence and length of human lambda light chains. Science, 157:1050.
Raska, K., Jr., and E. P. Cohen (1967). The specific activity of several enzymes of nucleotide metabolism in the mouse spleen after antigen. Clin. Exper. Immunol., in press.
Scherrer, K., and J. E. Darnell (1962). Sedimentation characteristics of rapidly-labeled RNA from HeLa cells. Biochem. Biophys. Res. Comm., 7:486.
Scherrer, K., H. Latham, and J. E. Darnell (1963). Demonstration of an unstable RNA and of a precursor to ribosomal RNA in HeLa cells. Proc. Nat. Acad. Sci., 49:240.
Smithies, O. (1963). Gamma-globulin variability: A genetic hypothesis. Nature, 199:1231.
Smithies, O. (1967). Antibody variability. Science, 157:267.
Talmage, D. W., and E. P. Cohen (1965). Antibody production and specificity in “Immunological Diseases.” M. Samter, ed. Little, Brown and Company, Boston, p. 87.
Watson, J. (1965). “The molecular biology of the gene.” New York: Benjamin (Bennett).
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Cohen, E.P., Raska, K. (1968). Unique Species of RNA in Peritoneal Cells Exposed to Different Antigens. In: Plescia, O.J., Braun, W. (eds) Nucleic Acids in Immunology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-87668-4_37
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DOI: https://doi.org/10.1007/978-3-642-87668-4_37
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