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Nucleic Acids in Immunology pp 114–124Cite as

DNA and Nucleoprotein Determinants for Systemic Lupus Erythematosus Sera

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Abstract

Studies of deoxyribonucleic acid (DNA) and nucleoprotein determinants for systemic lupus erythematosus (SLE) sera have had a two-fold objective. One goal has been to learn what structures act as immunizing agents in this disease, and the second, to characterize sera for use as immunochemical reagents in studies of DNA and nucleoprotein structure. The determinants have been explored mainly by: (1) comparisons of direct complement (C′)-fixation reactivity of native and denatured DNA, of nucleoprotein, and of artificial DNA-histone complexes; and (2) inhibition of C′-fixation by fragments of the antigens.

Research described in this article was supported in part by grants #GB2770 and GB5606 from the National Science Foundation.

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Author information

Authors and Affiliations

  1. Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts, USA

    B. David Stollar

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  1. B. David Stollar
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Editor information

Editors and Affiliations

  1. Institute of Microbiology, Rutgers, The State University, USA

    Otto J. Plescia  & Werner Braun  & 

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© 1968 Springer-Verlag New York Inc.

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Stollar, B.D. (1968). DNA and Nucleoprotein Determinants for Systemic Lupus Erythematosus Sera. In: Plescia, O.J., Braun, W. (eds) Nucleic Acids in Immunology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-87668-4_10

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  • DOI: https://doi.org/10.1007/978-3-642-87668-4_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-87670-7

  • Online ISBN: 978-3-642-87668-4

  • eBook Packages: Springer Book Archive

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