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Stiff-Man Syndrome

  • Hans-Michael Meinck
  • Karl M. Einhäupl
  • Werner Hacke

Abstract

Stiff-man syndrome (SMS) is a motor disorder characterized by stiffness of the axial muscles and painful spasms or jerks. Although SMS is usually regarded as a neurological curiosity, life-threatening complications may occur. The most important complication is paroxysmal dysfunction of the autonomic nervous system, which can range from dilated pupils to severe hypotension and shock. Other complications, resulting from treatment with sedatives or antispastic agents, include ventilatory depression or rebound worsening of symptoms in patients having withdrawal.

Keywords

Glutamic Acid Decarboxylase Dilate Pupil Intrathecal Baclofen Acute Disseminate Encephalomyelitis Reflex Inhibition 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Suggested Reading

  1. Lorish TR, Thorsteinsson G, Howard FM (1989) Stiff-man syndrome updated. Mayo Clin Proc 64: 629–636PubMedGoogle Scholar
  2. Meinck HM, Ricker K, Hülser PJ, Schmid E, Peiffer J, Solimena M (1994) Stiff-man syndrome: clinical, biochemical, and neuro-imaging findings in eight patients. J Neurol 241: 157–166PubMedCrossRefGoogle Scholar
  3. Mitsumoto H, Schwartzman MJ, Estes ML, Chou SM, la Franchise F, de Camilli P, Solimena M (1991) Sudden death and paroxysmal autonomic dysfunction in stiff-man syndrome. J Neurol 238: 91–96PubMedCrossRefGoogle Scholar
  4. Whiteley AM, Swash M, Urich H (1976) Progressive encephalomyelitis with rigidity. Brain 99: 27–42PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • Hans-Michael Meinck
  • Karl M. Einhäupl
  • Werner Hacke

There are no affiliations available

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