Stiff-man syndrome (SMS) is a motor disorder characterized by stiffness of the axial muscles and painful spasms or jerks. Although SMS is usually regarded as a neurological curiosity, life-threatening complications may occur. The most important complication is paroxysmal dysfunction of the autonomic nervous system, which can range from dilated pupils to severe hypotension and shock. Other complications, resulting from treatment with sedatives or antispastic agents, include ventilatory depression or rebound worsening of symptoms in patients having withdrawal.
KeywordsGlutamic Acid Decarboxylase Dilate Pupil Intrathecal Baclofen Acute Disseminate Encephalomyelitis Reflex Inhibition
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