Acute Disseminated Encephalomyelitis (Parainfectious and Postvaccinal Encephalitis)

  • Brigitte Storch-Hagenlocher
  • Diane E. Griffin
  • Karl M. Einhäupl
  • Werner Hacke


Acute disseminated encephalomyelitis (ADEM) is an autoimmune inflammatory demyelinating disease of the central nervous system. It may follow a viral infection, Mycoplasma and bacterial infection, or immunization. The most common viruses associated with ADEM are measles, rubella, and varicella zoster. ADEM is usually a monophasic illness, but some patients may have a fulminating, progressive, or relapsing course. Histopathology shows multifocal, perivascular (mostly perivenous) lymphocytic inflitration, demyelination, and focal necrosis infrequently associated with hemorrhage. The demyelinated plaques are usually smaller than those found in multiple sclerosis (MS).


Multiple Sc1erosis Optic Neuritis Demyelinating Disease Transverse Myelitis Viral Encephalitis 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • Brigitte Storch-Hagenlocher
  • Diane E. Griffin
  • Karl M. Einhäupl
  • Werner Hacke

There are no affiliations available

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