Neural Progestin Receptors: Regulation of Progesterone-Facilitated Sexual Behaviour in Female Guinea Pigs

  • J. D. Blaustein
  • T. J. Brown
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)

Abstract

Besides having influences on a variety of other aspects of behaviour and reproductive physiology, oestradiol and progesterone interact to regulate the display of sexual behaviours during the oestrous cycle of many vertebrate species (Young 1961). In oestrogen-primed female rodents, progesterone both facilitates the display of sexual behaviour and inhibits its further facilitation by progesterone (Morin 1977). The latter effect of progesterone has been called de sensitization (Blaustein 1982a, b). Both of these influences of progesterone are due to actions within the brain. In fact, both effects are seen after intracranial implantation of progesterone within the ventromedial hypothalamic area (Rubin and Barfield 1983, 1984; Morin and Feder 1974a).

Keywords

Cholesterol Formaldehyde Estrogen Dopamine Cortisol 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Blaustein JD (1982a) Alteration of sensitivity to progesterone facilitation of lordosis in guinea pigs by modulation of hypothalamic progestin receptors. Brain Res 243:287–300PubMedCrossRefGoogle Scholar
  2. Blaustein JD (1982b) Progesterone in high doses may overcome progesterone’s desensitization effect on lordosis by translocation of hypothalamic progestin receptors. Horm Behav 16:175–190PubMedCrossRefGoogle Scholar
  3. Blaustein JD (1984) Noradrenergic inhibitors cause accumulation of nuclear progestin receptors in guinea pig hypothalamus. Brain Res 325:89–98CrossRefGoogle Scholar
  4. Blaustein JD, Brown TJ (1983) Mechanisms of oestrogen-progestin interactions in the regulation of lordosis in female guinea pigs. In: Balthazart J, Prove E, Gilles R (eds) Hormones and behaviour in higher vertebrates. Springer, Berlin Heidelberg New York, p 18CrossRefGoogle Scholar
  5. Blaustein JD, Feder HH (1979a) Cytoplasmic progestin receptors in female guinea pig brain and their relationship to refractoriness in expression of female sexual behavior. Brain Res 177:489–498PubMedCrossRefGoogle Scholar
  6. Blaustein JD, Feder HH (1979b) Cytoplasmic progestin receptors in guinea pig brain: characteristics and relationship to the induction of sexual behavior. Brain Res 169:481–497PubMedCrossRefGoogle Scholar
  7. Blaustein JD, Feder HH (1980) Nuclear progestin receptors in guinea pig brain measured by an in vitro exchange assay after hormonal treatments that affect lordosis. Endocrinology 106: 1061–1069PubMedCrossRefGoogle Scholar
  8. Brown TJ, Blaustein JD (1984a) Inhibition of sexual behavior in female guinea pigs by a progestin receptor antagonist. Brain Res 301:343–349PubMedCrossRefGoogle Scholar
  9. Brown TJ, Blaustein JD (1984b) Supplemental progesterone delays heat termination and the loss of progestin receptors from hypothalamic cell nuclei in female guinea pigs. Neuroendocrinology 39:384–391PubMedCrossRefGoogle Scholar
  10. Brown TJ, Blaustein JD (1984c) o, p’-DDT induces functional progestin receptors in the rat hypothalamus and pituitary gland. Endocrinology 115:2052–2058PubMedCrossRefGoogle Scholar
  11. Crowley WR, Feder HH, Morin LP (1976) Role of monoamines in sexual behavior of the female guinea pig. Pharmacol Biochem Behav 4:67–71PubMedCrossRefGoogle Scholar
  12. Etgen A (1983) l-(o-Chlorophenyl)-l-(p-chlorophenyl)2,2,2-trichloroethane: a probe for studying estrogen and progestin receptor mediation of female sexual behavior and neuroendocrine responses. Endocrinology 111:1498–1504CrossRefGoogle Scholar
  13. Gorski J, Gannon F (1975) Current models of steroid hormone action: a critique. Annu Rev Physiol 38:425–450CrossRefGoogle Scholar
  14. Heritage AS, Grant LD, Stumpf WE (1977) H-Estradiol in catecholamine neurons of rat brain stem: combined localization by autoradiography and formaldehyde induced fluorescence. J Comp Neurol 176:607–630PubMedCrossRefGoogle Scholar
  15. Herrmann W, Wyss R, Riondel D, Teutsch G, Sakiz E, Baulieu EE (1982) Effet d’un stéroide anti- progestérone chez la femme: interruption du cycle menstruel et de la grossesse au début. CR Acad Sci Paris 294:933–938Google Scholar
  16. King WJ, Greene GL (1984) Monoclonal antibodies localize oestrogen receptor in the nuclei of target cells. Nature (Lond) 307:745–747CrossRefGoogle Scholar
  17. Lisk RD (1978) The regulation of sexual “heat”. In: Hutchison J (ed) Biological determinants of sexual behavior. Wiley, New York, p 425Google Scholar
  18. MacLusky NJ, McEwen BS (1978) Oestrogen modulates progestin receptor concentrations in some rat brain regins, but not in others. Nature (Lond) 274:276–277CrossRefGoogle Scholar
  19. McGinnis M, Parsons B, Rainbow TC, Krey LC, McEwen BS (1981) Temporal relationship between cell nuclear progestin receptor levels and sexual receptivity following intravenous progesterone administration. Brain Res 218:365–371PubMedCrossRefGoogle Scholar
  20. Moguilewsky M, Philibert D (1984) RU 38486: potent antiglucocoticoid activity correlated with strong binding to the cytosolic glucocorticoid receptor followed by an impaired activation. J Steroid Biochem 20:271–276PubMedCrossRefGoogle Scholar
  21. Morin LP (1977) Progesterone: inhibition of rodent behavior. Physiol Behav 18:701–715PubMedCrossRefGoogle Scholar
  22. Morin LP, Feder HH (1973) Multiple progesterone injections and the duration of estrus in ovari-ectomized guinea pigs. Physiol Behav 11:861–865PubMedCrossRefGoogle Scholar
  23. Morin LP, Feder HH (1974a) Hypothalamic progesterone implants and facilitation of lordosis behavior in estrogen-primed ovariectomized guinea pigs. Brain Res 70:81–93PubMedCrossRefGoogle Scholar
  24. Morin LP, Feder HH (1974b) Inhibition of lordosis behavior in ovariectomized guinea pigs by mesencephalic implants of progesterone. Brain Res 70:71–80PubMedCrossRefGoogle Scholar
  25. Morin LP, Feder HH (1974c) Intracranial estradiol benzoate implants and lordosis behavior of ovariectomized guinea pigs. Brain Res 70:95–102PubMedCrossRefGoogle Scholar
  26. Nock B, Feder HH (1979) Noradrenergic transmission and female sexual behavior of guinea pigs. Brain Res 166:369–380PubMedCrossRefGoogle Scholar
  27. Nock B, Blaustein JD, Feder HH (1981) Changes in noradrenergic transmission alter the concentration of cytoplasmic progestin receptors in hypothalamus. Brain Res 207:371–396PubMedCrossRefGoogle Scholar
  28. OMalley BW, Means AR (1974) Female steroid hormones and target cell nuclei. Science (Wash DC) 183:610–624CrossRefGoogle Scholar
  29. Parsons B, MacLusky NJ, Krey L, Pfaff DW, McEwen BS (1980) The temporal relationship between estrogen-inducible progestin receptors in the female rat brain and the time course of estrogen activation of mating behavior. Endocrinology 107:774–779PubMedCrossRefGoogle Scholar
  30. Phüibert D, Deraedt R, Teutsch G, Toumemine C, Sakiz E (1982) RU 38486 - a new lead for steroidal antihormones. In: 65th meeting endocrine society, abstract number 668Google Scholar
  31. Rubin BS, Barfield RJ (1980) Priming of estrous responsiveness by implants of 17/3-estradiol in the ventromedial hypothalamic nucleus of female rats. Endocrinology 106:504–509PubMedCrossRefGoogle Scholar
  32. Rubin BS, Barfield RJ (1983) Progesterone in the ventromedial hypothalamus facilitates estrous behavior in ovariectomized, estrogen-primed rats. Endocrinology 113:797–804PubMedCrossRefGoogle Scholar
  33. Rubin BS, Barfield RJ (1984) Progesterone in the ventromedial hypothalamus of ovariectomized estrogen-primed rats inhibits subsequent facilitation of estrous behavior by systemic progesterone. Brain Res 294:1–8PubMedCrossRefGoogle Scholar
  34. Sheridan P, Buchanan JM, Anselmo VC, Martin PM (1979) Equilibrium: the intracellular distribution of steroid receptors. Nature (Lond) 282:579–582CrossRefGoogle Scholar
  35. Welshons WV, Lieberman ME, Gorski J (1984) Nuclear localization of unoccupied oestrogen receptors. Nature (Lond) 307:747–749CrossRefGoogle Scholar
  36. Young WC (1961) The hormones and mating behavior. In: Young WC (ed) Sex and internal secretions. Williams and Wilkins, Baltimore, p 1173Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • J. D. Blaustein
  • T. J. Brown
    • 1
  1. 1.Division of Neuroscience and Behavior, Department of PsychologyUniversity of MassachusettsAmherstUSA

Personalised recommendations