Skip to main content

Über neurogene Wirkungen von Ruta graveolens

  • Conference paper
Book cover Naturheilverfahren

Zusammenfassung

Die Wein-oder Gartenraute, Ruta graveolens (Abb. 1), gehört wie der bei uns seltene Diptam zur Familie der Rutaceen. Diese sind in gemäßigt trok-ken-warmen Regionen verbreitete, etwa 60 Arten umfassende strauchartige Gewächse. Wäßrige Auszüge von Ruta graveolens und Ruta chalepensis werden, per os appliziert, vorwiegend in einigen Ländern Südamerikas, aber auch in Indien und anderenorts in der Volksmedizin u. a. als Antihelminthikum, Emetikum, Abortivum und interessanterweise als Spasmolytikum und Lokalanästhetikum eingesetzt [Minker et al., 1979; Montes Giraldo, 1981]. Besonders bemerkenswert erschienen uns die in fast allen Quellen ähnlich wiederkehrenden Angaben über günstige Wirkungen auf die gestörte Motorik.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Armstrong CM (1971) Interaction of tetraethylammonium ion derivatives with the potassium channels of giant axons. J Gen Physiol 58413–437

    Article  PubMed  CAS  Google Scholar 

  • Berthold C-H, Rydmark M (1983) VI. Anatomy of the paranode-node-paranode in the cat. Experientia 39954–976

    Article  Google Scholar 

  • Bohuslavizki KH, Koppenhöfer E, Hänsel W, Möller W-D (1988) A new approach for the treatment of demyelinating diseases? J Neuroimmunology 20251–252

    Article  CAS  Google Scholar 

  • Bostock H, Sears TA (1978) The internodal axon membrane electrical excitability and continuous conduction in segmental demyelination. J Physiol (London) 280273–301

    CAS  Google Scholar 

  • Braun H, Frohne D (1987) Heilpflanzenlexikon für Ärzte und Apotheker. Gustav Fischer Verlag, Stuttgart

    Google Scholar 

  • Brismar T (1981) Specific permeability properties of demyelinated rat nerve fibres. Acta physiol scand 113167–176

    Article  PubMed  CAS  Google Scholar 

  • Brismar T (1983) IV. Nodal function of pathological nerve fibers. Experientia 39946–953

    Article  PubMed  CAS  Google Scholar 

  • Chiu SY, Ritchie JM (1982) Evidence for the presence of potassium channels in the internode of frog myelinated nerve fibres. J Physiol (London) 322485–501

    CAS  Google Scholar 

  • Davis FA, Stefoski D, Bindokas J, Schauf CL (1986) 4-Aminopyridine administered orally improves clinical signs in multiple sclerosis. Ann Neurol 20152

    Article  Google Scholar 

  • Deutsches Arzneibuch, 8. Ausgabe 1978 Deutscher Apotheker Verlag, Stuttgart, Govi Verlag, Frankfurt

    Google Scholar 

  • Dodge FA, Frankenhaeuser B (1958) Membrane currents in isolated frog nerve fibre under voltage clamp conditions. J Physiol (London) 14376–90

    CAS  Google Scholar 

  • Eilert U, Ehmke A, Wolters B (1984) Elicitor-induced accumulation of acridon alkaloid epoxides in Ruta graveolens suspension cultures. Planta medica 1984, 508–512

    Article  Google Scholar 

  • Frankenhaeuser B (1957) A method for recording resting and action potential in the isolated myelinated nerve fibre of the frog. J Physiol (London) 135550–559

    CAS  Google Scholar 

  • Frankenhaeuser B (1959) Steady state inactivation of sodium permeability in myelinated nerve fibres of Xenopus laevis. J Physiol (London) 148671–676

    CAS  Google Scholar 

  • Frankenhaeuser B, Hodgkin AL (1957) The action of calcium on the electrical properties of squid axons. J Physiol (London) 137217–244 (1957)

    Google Scholar 

  • Frankenhaeuser B, Moore LE (1963) The effect of temperature on the sodium and potassium permeability changes in myelinated nerve fibres of Xenopus laevis. J Physiol (London) 169431–437

    CAS  Google Scholar 

  • Fricke E (1987) Multiple Sklerose. Edition Medizin, Verlag Chemie, Weinheim

    Google Scholar 

  • Gardner-Medwin AR (1986) A new framework for assessment of potassium-buffering mechanisms. Ann NY Acad Sci 481287–302

    Article  CAS  Google Scholar 

  • Häfele F, Schimmer O (1988) Quantitative Bestimmung von gentoxischen Furochinolinal-kaloiden in Auszügen von Dictamni radix mittels HPLC und Ermittlung der mutagenen Potenz im Salmonella/microsome Test. Arch Pharm (Weinheim) 321693

    Google Scholar 

  • Henn FA, Haljamäe H, Hamberger A (1972) Glial cell function Action of extracellular K+ concentration. Brain Res 43437–443

    Article  PubMed  CAS  Google Scholar 

  • Hille B (1968) Charges and potentials at the nerve surface. Divalent ions and pH. J Gen Physiol 51221–236

    Article  PubMed  CAS  Google Scholar 

  • Hodgkin AL, Huxley AF (1952) A quantitative description of membrane current and its application to conductance and excitation in nerve. J Physiol (London) 117500–544

    CAS  Google Scholar 

  • Homöopathisches Arzneibuch, I. Ausgabe 1978 Deutscher Apotheker Verlag, Stuttgart, 1986

    Google Scholar 

  • Huxley AL, Stämpfli R (1949) Evidence for saltatory conduction in peripheral myelinated nerve fibres. J Physiol (London) 108315–339

    Google Scholar 

  • Huxley AL, Stämpfli R (1951) Effect of potassium and sodium on resting and action potentials of single myelinated nerve fibres. J Physiol (London) 112496–508

    CAS  Google Scholar 

  • Jones RE, Ileson JR, Foster DH, Snolgar RS, Mason RJ (1983) Effects of 4-Aminopyri-dine in patients with Multiple Sclerosis. J Neurological Sci 60353–362

    Article  CAS  Google Scholar 

  • Kocsis JD, Waxman SG (1985) Demyelination causes and mechanisms of clinical abnormality and functional recovery. In Handbook of clinical Neurology. Bd 3 (47). De-myelinating diseases. Hrsg. Vinken PJ, Bruyn GW, Klawans HL, Koetsier JC, S 29–47, Elsevier, Amsterdam

    Google Scholar 

  • Koppenhöfer E, Sommer R-G, Froese U (1987) Effects of benzocaine and its isomers on sodium permeability and steady state inactivation in the myelinated nerve, obtained by an improved dissection technique. Gen Physiol Biophys 6209–222

    PubMed  Google Scholar 

  • Kubeczka KH(1971) Die ätherischen Öle verschiedener Ruta-Arten. Herba Hungarica 20109–117

    Google Scholar 

  • Kuhn TS (1977) Die Entstehung des Neuen. Hrsg. Krüger L, Suhrkamp, Frankfurt/Main

    Google Scholar 

  • Lehmann HJ, Ule G (1964) Electrophysiological findings and structural changes in cir-cumscript inflammation of peripheral nerves. Progress in Brain Res 6169–173

    Article  Google Scholar 

  • Marmont G (1949) Studies on the axon membrane. I. A new method. J Cell Comp Physiol 34351–382

    Article  CAS  Google Scholar 

  • Maurer K, Lowizsch K, Stöhr M (1988) Evozierte Potentiale. AEP-VEP-SEP. Enke, Stuttgart

    Google Scholar 

  • Minker E, Bartha C, Rózsa Z, Szendrei K, Reisch J (1979) Antispasmogenic effect of Rutamarin and Arborinine on isolated smooth muscle organs. Planta Medica 37156–160

    Article  PubMed  CAS  Google Scholar 

  • Montes Giraldo J J (1981) Medicina popular en Colombia -vegetales y ortas sustancias usadas como remedios. Publicaciones del instituto caro y cuervo LVIII, Bogota

    Google Scholar 

  • Nahrstedt A, Wray V, Engel B, Reinhard E (1984) New furoacridone alkaloids from tissue culture of Ruta graveolens. Planta Medica 1984, 517–519

    Google Scholar 

  • Nonner W (1969) A new voltage clamp method for Ranvier nodes. Pflügers Arch 309176–192

    Article  PubMed  CAS  Google Scholar 

  • Nuver MR, Namerov NS (1981) Somatosensory evoked potential testing in Multiple Sclerosis. Adv Neurol 31183–199

    Google Scholar 

  • Petit-Paly G, Rideau M, Chenieux JC (1982) Étude de quelques Rutacées a Alcaloides. II. Ruta graveolens Revue Botanique, Chimique et Pharmacologique (Études particu-lière des Alcaloides quarternaires Quinoléiques). P1 Méd et Phytoth 1655–72

    CAS  Google Scholar 

  • Poeck K (1987) Neurologie. Springer, Heidelberg

    Google Scholar 

  • Raine CS (1984) Biology of disease. Analysis of autoimmune demyelination its impact upon Multiple Sclerosis. Lab Invest 50608–635

    PubMed  CAS  Google Scholar 

  • Ramón F, Anderson N, Joyner RW, Moore JW (1975) Axon voltage clamp simulations. IV. A multicellular preparation. Biophys J 1555–69

    Article  PubMed  Google Scholar 

  • Rasminsky M, Sears TA (1972) Internodal conduction in undissected demyelinated nerve fibres. J Physiol (London) 227323–350

    CAS  Google Scholar 

  • Reisch J, Rózsa Z, Mester I (1978) Über die Struktur des Rutacridons (1). Z Naturforsch 33b957–958

    CAS  Google Scholar 

  • Ritchie JM, Chiu SY (1981) Distribution of sodium and potassium channels in mammalian myelinated nerve. Adv Neurol 31329–340

    PubMed  CAS  Google Scholar 

  • Ritchie JM, Rang HP, Pellegrino R (1981) Sodium and potassium channels in demyelinated and remyelinated mammalian nerve. Nature 294257–259

    Article  PubMed  CAS  Google Scholar 

  • Ritchie JM, Rogart RB (1977) Density of sodium channels in mammalian myelinated nerve fibers and nature of the axonal membrane under the myelin sheath. Proc Natl Acad Sci USA 74211–215

    Article  PubMed  CAS  Google Scholar 

  • Schneider G (1965) Verteilung vom Dictamnin und -Fagarin in Ruta graveolens L. Planta Medica 13425–430

    Article  CAS  Google Scholar 

  • Schönle C, Koppenhöfer E (1983) Zur Selektivität der Wirkung gereinigten Tetraäthylammoniumchlorids am Ranvierschen Schnürring. Funkt Biol Med 249–52

    Google Scholar 

  • Schumann H, Koppenhöfer E, Wiese H (1983) Compensation of the low-pass filter properties of the current measuring internode in potential-clamped myelinated nerve fibre. Gen Physiol Biophys 2287–295

    PubMed  CAS  Google Scholar 

  • Schwarz JR, Vogel W (1971) Potassium inactivation in single myelinated nerve fibres of Xenopus laevis. Pflügers Arch 330, 61–73

    Article  PubMed  CAS  Google Scholar 

  • Sherrat RM, Bostock H, Sears TA (1980) Effects of 4-Aminopyridine on normal and demyelinated mammalian nerve fibres. Nature 283570–572

    Article  Google Scholar 

  • Stefoski D, Davis FA, Faut M, Schauf CL (1987) 4-Aminopyridine improves clinical signs in Multiple Sclerosis. Ann Neurol 2171–77

    Article  PubMed  CAS  Google Scholar 

  • Swenson Jr RP (1981) Inactivation of potassium current in squid by a variety of quarter-nary ammonium ions. J Gen Physiol 77255–271

    Article  PubMed  CAS  Google Scholar 

  • Ulbricht W, Wagner HH, Schmidtmayer J (1982) Effects of aminopyridines on potassium currents of the nodal membrane. In Advances in the Biosciences. Vol. 35. Aminopyridines and similarily acting drugs. Hrsg. Lechat P, Thessleff S, Bowman WC, S 29–41, Pergamon press, Oxford

    Google Scholar 

  • Waksman BH, Adams RD (1956) Comparative study of experimental allergic neuritis in the rabbit, guinea pig and mouse. J Neuropathol Exp Neurol 15293–234

    Article  PubMed  CAS  Google Scholar 

  • Waxman SG (1977) Conduction in myelinated, unmyelinated, and demyelinated fibers. Arch Neurol 34585–589

    Article  PubMed  CAS  Google Scholar 

  • Waxman SG (1981) Clinicopathological correlations in Multiple Sclerosis and related diseases. Adv Neurol 31169–182

    PubMed  CAS  Google Scholar 

  • Waxman SG (1986) Functional organization of the axon membrane in normal and pathological fibers. X. International Congress of Neuropathology, Stockholm

    Google Scholar 

  • Waxman SG, Ritchie JM (1985) Organization of ion channels in the myelinated nerve fiber. Science 2281502–1507

    Article  PubMed  CAS  Google Scholar 

  • Wolters B, Eilert U (1981) Antimicrobial substances in callus cultures of Ruta graveolens. Planta medica 43166–174

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Springer-Verlag, Berlin Heidelberg New York

About this paper

Cite this paper

Bautz, C., Bohuslavizki, K.H., Hänsel, W., Kneip, A., Koppenhöfer, E., Möller, WD. (1990). Über neurogene Wirkungen von Ruta graveolens . In: Albrecht, H., Franz, G. (eds) Naturheilverfahren. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-87580-9_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-87580-9_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-50956-1

  • Online ISBN: 978-3-642-87580-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics