NMR spectroscopy From experimental to clinical spectroscopy

  • J. Bittoun
  • A. Leroy-Willig


Soon after its discovery, the nuclear magnetic resonance (NMR) phenomenon became one of the most important tools of chemical analysis, which allowed the in vitro analysis of substances without splitting the molecules. In NMR, the excitation of a chemical element by a radiofrequency wave is sufficient to obtain a signal providing a great deal of information about the structure of the molecule this element belongs to. It is then theoretically possible to study biologically interesting molecules in animals or even in man, thus allowing chemical analysis leading to the direct observation of cell metabolism. In medical practice, this technique was not feasible until magnets with an intense field strength were built with an inside diameter large enough for the human body. The fast development of magnetic resonance imaging (MRI) raised early hopes that the same system would provide both images of an organ and chemical analysis of one localized area of these images.


Nuclear Magnetic Reso Nuclear Magnetic Resonance Spectroscopy Nuclear Magnetic Reso Nuclear Magnetic Reso Imaging Hydrogen Nucleus 
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© Springer-Verlag France 1989

Authors and Affiliations

  • J. Bittoun
  • A. Leroy-Willig

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