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An Analysis of the Mechanism of Carcinogenesis by Polyoma Virus, Hydrocarbons, and X-Irradiation

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Molekulare Biologie des Malignen Wachstums

Abstract

Tumor cells can replicate under conditions when normal cells cannot, because to varying degrees depending on the tumor, their replication is not inhibited by controls that inhibit the replication of normal cells. The basic process responsible for the change of a normal cell into a tumor cell is thus a change in the control mechanism for cell replication. The mechanisms that control the replication of normal cells can be divided into 2 types; those in which circulating substances produced by one cell control the growth of another cell, and those that appear to be mediated by cell surface interactions. This second type of control will be referred to as contact inhibition1. The experiments to be presented are concerned with our in vitro studies on the mechanism of the change in the contact inhibition control for cell replication that is induced by carcinogenic agents. Carcinogenesis can be induced by viruses, non-viral chemicals, and physical agents. The present experiments will therefore be concerned with the change in this control induced by small DNA tumor viruses with particular reference to polyoma virus, carcinogenic hydrocarbons, and x-irradiation. The change in control resulting in a change of a normal cell into a tumor cell will be referred to as transformation.

Supported by Research Grant CA 05266 from the National Cancer Institure, US. Public Health Service.

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References

  1. Abercrombie, M., and E. J. Ambrose: Cancer Res. 22, 52 (1962).

    Google Scholar 

  2. Sachs, L., and D. Medina: Nature (Lond.) 189, 457 (1961).

    Article  CAS  Google Scholar 

  3. Vogt, M., and R. Dulbecco: Proc. nat. Acad. Sci. (Wash.) 46, 365 (1960).

    Article  CAS  Google Scholar 

  4. Berwald, Y., and L. Sachs: Nature (Lond.) 200, 1182 (1963).

    Article  CAS  Google Scholar 

  5. Berwald, Y., and L. Sachs: J. nat. Cancer Inst. 35, 641 (1965).

    PubMed  CAS  Google Scholar 

  6. Borek, C., and L. Sachs: Nature (Lond.) 210, 276 (1966).

    Article  CAS  Google Scholar 

  7. Stoker, M., and I. MacPherson: Virology 14, 359 (1961).

    Article  Google Scholar 

  8. Sachs, L., D. Medina, and Y. Berwald: Virology 17, 491 (1962).

    Article  PubMed  CAS  Google Scholar 

  9. Medina, D., and L. Sachs: Virology 19, 127 (1963).

    Article  Google Scholar 

  10. Medina, D., and L. Sachs: Virology 27, 398 (1965).

    Article  PubMed  CAS  Google Scholar 

  11. Sachs, L.: In New Perspectives in Biology, p. 246. Elsevier Co. 1964.

    Google Scholar 

  12. Huberman, E., and L. Sachs: To be published.

    Google Scholar 

  13. MacPherson, I., and L. Montagnier: Virology 23, 291 (1964).

    Article  PubMed  CAS  Google Scholar 

  14. Borek, C., and L. Sachs: To be published.

    Google Scholar 

  15. Todaro, G. J., and H. Green: Proc. nat. Acad. Sci. (Wash.) 55, 302 (1966).

    Article  CAS  Google Scholar 

  16. Winocour, E., A. M. Kaye, and V. Stollar: Virology 27, 156 (1965).

    Article  PubMed  CAS  Google Scholar 

  17. Winocour, E., A. M. Kaye, and V. Stollar: To be published.

    Google Scholar 

  18. Dulbecco, R., L. H. Hartwell, and M. Vogt: Proc. nat. Acad. Sci. (Wash.) 53, 403 (1965).

    Article  CAS  Google Scholar 

  19. Gershon D., P. Hausen, L. Sachs, and E. Winocour: Proc. nat. Acad. Sci. (Wash.) 54,1584 (1965).

    Article  CAS  Google Scholar 

  20. Sheinin, R.: Virology 28, 621 (1966).

    Article  PubMed  CAS  Google Scholar 

  21. Gershon, D., L. Sachs, and E. Winocour: Proc. nat. Acad. Sci. (Wash). In press.

    Google Scholar 

  22. Weil, R., M. R. Michel, and G. K. Ruschman: Proc. nat. Acad. Sci. (Wash.) 53,1468 (1965).

    Article  CAS  Google Scholar 

  23. Medina, D., and L. Sachs: Brit. J. Cancer 15, 885 (1961).

    Article  PubMed  CAS  Google Scholar 

  24. Weil, R., and J. Vinograd: Proc. nat. Acad. Sci. (Wash.) 50, 730 (1963).

    Article  CAS  Google Scholar 

  25. Crawford, L. V.: Virology 22,149 (1964).

    Article  CAS  Google Scholar 

  26. Kass, S.: To be published.

    Google Scholar 

  27. Medina, D., and L. Sachs: Virology 10, 387 (1960).

    Article  Google Scholar 

  28. Sachs, L., and D. Medina: Nature (Lond.) 187, 715 (1960).

    Article  CAS  Google Scholar 

  29. Winocour, E., and L. Sachs: J. nat. Cancer Inst. 26, 737 (1961).

    PubMed  CAS  Google Scholar 

  30. Gershon, D., and L. Sachs: Virology 27,120 (1965).

    Article  PubMed  CAS  Google Scholar 

  31. Ossowski, L., and L. Sachs: To be published.

    Google Scholar 

  32. Sachs, L., M. Fogel, and E. Winocour: Nature (Lond.) 183, 663 (1959).

    Article  CAS  Google Scholar 

  33. Winocour, E., and L. Sachs: Virology 8, 397 (1959).

    Article  PubMed  CAS  Google Scholar 

  34. Sachs, L.: Nature (Lond.) 207,1272 (1965).

    Article  CAS  Google Scholar 

  35. Winocour, E., and L. Sachs: Virology 11, 699 (1960).

    Article  PubMed  CAS  Google Scholar 

  36. Hare J. D., and T. Godal: Proc. Soc. exp. Biol. (N.Y.) 118, 632 (1965).

    CAS  Google Scholar 

  37. Klein, G.: In New Perspectives in Biology, p. 261. Elsevier Co. 1964.

    Google Scholar 

  38. Stoker, M.: Virology 24,165 (1964).

    Article  PubMed  CAS  Google Scholar 

  39. Barski, G., and J. Belehradek: Exp. Cell Res. 37, 464 (1965).

    Article  PubMed  CAS  Google Scholar 

  40. Friedewald, W. F., and P. Rous: J. exp. Med. 80, 101 (1944).

    Article  PubMed  CAS  Google Scholar 

  41. Berenblum, I., and P. Shubik: Brit. J. Cancer 1, 383 (1947).

    Article  PubMed  CAS  Google Scholar 

  42. Berenblum, I., and P. Shubik: Cancer Res. 14, 471 (1954).

    PubMed  CAS  Google Scholar 

  43. Haddow, A.: J. Path. Bact. 47, 581 (1938).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Section of Genetics, Weizmann Institute of Science, Rehovoth, Israel

    L. Sachs

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  1. L. Sachs
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H. Holzer A. W. Holldorf

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© 1966 Springer-Verlag Berlin · Heidelberg

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Sachs, L. (1966). An Analysis of the Mechanism of Carcinogenesis by Polyoma Virus, Hydrocarbons, and X-Irradiation. In: Holzer, H., Holldorf, A.W. (eds) Molekulare Biologie des Malignen Wachstums. Colloquium der Gesellschaft für Physiologische Chemie am 21./23. April 1966 in Mosbach/Baden, vol 17. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-87539-7_23

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  • DOI: https://doi.org/10.1007/978-3-642-87539-7_23

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-03481-0

  • Online ISBN: 978-3-642-87539-7

  • eBook Packages: Springer Book Archive

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