Sympathetic nervous system activity in the obese hypertensive patient: potential role for central alpha-adrenoreceptor agonists

  • Michael Tuck


In most industrialized populations a strong association between blood pressure and body weight has been established. Several large-scale studies in the United States have confirmed the relationship between obesity and hypertension (the Framing-ham Study (Kannel et al. 1967); the Evans Country, Georgia Study (Tyroler et al. 1975); the Community Hypertension Evaluation Clinic (Stamler et al. 1978); Hypertensive Detection and Follow-up Program Cooperative Group (1979)). In the Evans county, Georgia study it was demonstrated prospectively that weight gain can increase blood pressure. Over the six-year period of the study, weight gain was associated with a two-fold possibility of developing hypertension. The converse was also true: subjects who were hypertensive at outset gained more weight. In those who were both obese and hypertensive at the outset, a weight reduction programme averaging 8 kg per patient produced very pronounced decrements in both systolic and diastolic blood pressure over a year. Comparing black and white subjects, it was concluded that obese white hypertensives benefited more than blacks from weight loss.


Weight Reduction Sympathetic Nervous System Obese Subject Plasma Renin Activity Sodium Intake 
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Copyright information

© Dr. Dietrich Steinkopff Verlag, GmbH & Co. KG, Darmstadt 1984

Authors and Affiliations

  • Michael Tuck
    • 1
  1. 1.Endocrinology and MetabolismVA Medical CenterSepulvedaUSA

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