Epigenetic Factors in the Neoplastic Response to Polyoma Virus
One could hardly speak of epigenetic matters before an audience at the University of Chicago without taking cognizance of the outstanding contributions that have come from that institution to the field of epigenetics. Among them, and quite relevant to the work described in this report, are the classical works of Dr. F. R. Lillie and Dr. Hsi Wang on the formation of feathers. In a series of experiments that lead to the delineation of the specific morphogenetic functions of the epithelial and the mesenchymal components of feather follicles (1), Dr. Lillie and Dr. Wang developed a pattern of analysis that has found increasing use in developmental biology, and is beginning to find application in experimental oncology. It is safe to predict that the debt of oncologists to those original investigations will continue to increase.
KeywordsSalivary Gland Salivary Gland Tumor Epigenetic Factor Odontogenic Tumor Polyoma Virus
Unable to display preview. Download preview PDF.
- 1.Wang, H.: The morphogenetic functions of the epidermal and dermal components of the papilla in feather regeneration. Physio. Zool. 16:325–350, 1943.Google Scholar
- 2.Dawe, C. J.: Cell sensitivity and specificity of response to polyoma virus. National Cancer Institute Monograph No. 4, pp. 67–128. Washington, D. C., U. S. Government Printing Office, 1960.Google Scholar
- 3.Aristotle: On the generation of animals. See especially Book II, Chapter 1, Berlin No. 734a, translated by D’Arcy Wentworth Thompson. In The Works of Aristotle. Chicago, Encyclopaedia Britannica, Inc., 1952, vol. 2.Google Scholar
- 4.Oppenheimer, Jane M.: Problems, Concepts and Their History. In Analysis of Development. Willier, B. H., Weiss, P. A., and Hamburger, V. (Eds.), Philadelphia, W. B. Saunders Company, 1955, pp. 1–24.Google Scholar
- 5.Dawe, C. J., and Law, L. W.: Morphologic changes in salivary-gland tissue of the newborn mouse exposed to parotid tumor agent in vitro. J. Nat. Cancer Inst. 23:1157–1177, 1959.Google Scholar
- 7.Dawe, C. J., Morgan, W. D., and Slatick, M. S.: Influence of epithelio-mesenchymal interactions on tumor induction by polyoma virus. Int. J. Cancer. In press. Google Scholar
- 11.Dawe, C. J., Law, L. W., and Dunn, T. B.: Studies of parotid-tumor agent in cultures of leukemic tissues of mice. J.. Nat. Cancer Inst. 23:717–797, 1959.Google Scholar
- 14.Friedman-Kien, A. E., Dawe, C. J., and Van Scott, E. J.: Hair growth cycle in subcutaneous implants of skin. J. Invest. Dermatology. 43:445–450, 1964.Google Scholar
- 16.Stanley, H. R., Baer, P. N., and Kilham, L.: Oral tissue alterations in mice inoculated with the Rowe substrain of polyoma virus. Periodontics. 3:178–183, 1965.Google Scholar
- 17.Main, J. H. P., and Dawe,C. J.: Tumor induction in transplanted tooth buds infected with polyoma virus. J. Nat. Cancer Inst. In press. Google Scholar
- 21.Foulds, L.: Some problems of differentiation and integration in neoplasia. In Biological Organization at the Cellular and Supercellular Level. Harris, R. J. C. (Ed.), New York, Academic Press, 1963, pp. 229–244.Google Scholar
- 22.McLoughlin, C. B.: The importance of mesenchymal factors in the differentiation of chick epidermis. II. Modification of epidermal differentiation by contact with different types of mesenchyme. J. Embryol. Exp. Morphol. 9:385–409, 1961.Google Scholar