Ferritin and haemosiderin

  • Pauline M. Harrison


Storage iron occurs in two physically different forms known as ferritin and haemosiderin. These are present in various organs, especially in the liver, spleen, and red bone marrow. The levels of ferritin and haemosiderin are increased during rapid breakdown of haemoglobin (Granick, 1946 a), and tracer experiments confirm that haemoglobin iron can be transferred to haemosiderin and ferritin (Hahn et al., 1943). Ferritin and haemosiderin are also formed in response to the administration of large amounts of various iron compounds (Granick and Hahn, 1944; Granick, 1946; Kuff and Dalton, 1957; Richter, 1957, 1959a; Bessis and Breton-Gorius, 1959; Muir and Goldberg, 1961; Therayothin and Crosby, 1962), the relative amounts of iron appearing in the ferritin and haemosiderin fractions depending on a number of factors (Shoden et al., 1953; Shoden and Sturgeon, 1958, 1959).


Sedimentation Coefficient Ferric Hydroxide Protein Shell Ferrous Ammonium Sulphate Hydrated Iron Oxide 
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© Springer-Verlag OHG · Berlin · Göttingen · Heidelberg 1964

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  • Pauline M. Harrison

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