Acute Respiratory Distress Syndrome

  • Paul Ellis Marik


The adult respiratory distress syndrome (ARDS) was initially described by Petty and Ashbaugh as a syndrome characterized by diffuse pulmonary infiltrates, with decreased pulmonary compliance and hypoxemia. It has been recognized, however, that ARDS is a spectrum varying from mild acute lung injury (ALI) at one end to ARDS at the other. The diagnosis of ARDS should be reserved for patients with ALI who have severe disease (see criteria below). The outcome of ALI is largely dependent on both the severity of ALI and the causative factors. It should be emphasized that in most cases ALI is a multisystem disease; the microcirculatory changes that occur in the lung occur in all the organs; the pathophysiological derangements, however, are most evident in the lung.


Acute Lung Injury Acute Respiratory Distress Syndrome Pulmonary Capillary Wedge Pressure Adult Respiratory Distress Syndrome Inspiratory Time 
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Copyright information

© Springer-Verlag New York, Inc. 2001

Authors and Affiliations

  • Paul Ellis Marik
    • 1
  1. 1.Critical Care MedicineMercy Hospital of PittsburghPittsburghUSA

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